UPF2 and TNNI2

Data Source:
BioGRID (two hybrid)

		UPF2	TNNI2
Description		UPF2 regulator of nonsense mediated mRNA decay	troponin I2, fast skeletal type
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Polysome Exon-exon Junction Complex Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm	Nucleus Cytosol Troponin Complex
	Molecular Function	RNA Binding Protein Binding Telomeric DNA Binding	Actin Binding Protein Binding Troponin T Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Animal Organ Regeneration	Skeletal Muscle Contraction Muscle Contraction Regulation Of Muscle Contraction Muscle Filament Sliding Positive Regulation Of Transcription, DNA-templated Cardiac Muscle Contraction
Pathways		Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Striated Muscle Contraction
Drugs
Diseases			Distal arthrogryposis (DA)
GWAS		Diverticular disease ( 30177863)	Celiac disease ( 23936387) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Inflammatory bowel disease ( 23128233) Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		76 interacting genes: ABCF2 AGPAT1 AKTIP ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MTREX MYB NDUFA7 NOB1 NOMO1 NOP53 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SMG1 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44	21 interacting genes: ACTB C1orf109 CALM1 CTNNA3 DCAF11 EFCAB2 ESRRA ESRRG HNF4G MNS1 NME7 PKD2L1 PSMC5 RORB TNNC1 TNNC2 TNNT1 TNNT3 TRIM55 TRIM63 UPF2
Entrez ID		26019	7136
HPRD ID		10405	01843
Ensembl ID		ENSG00000151461	ENSG00000130598
Uniprot IDs		Q9HAU5	P48788
PDB IDs		1UW4 2WJV 4CEK 4CEM	2MKP
Enriched GO Terms of Interacting Partners?
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