RNF19A and SNCAIP

Data Source:
HPRD (in vitro)

		RNF19A	SNCAIP
Description		ring finger protein 19A, RBR E3 ubiquitin protein ligase	synuclein alpha interacting protein
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Centrosome Cytosol Integral Component Of Membrane Hippocampal Mossy Fiber To CA3 Synapse Postsynapse Glutamatergic Synapse	Nucleoplasm Cytoplasm Cytosol Synaptic Vesicle Cytoplasmic Ribonucleoprotein Granule Presynaptic Membrane Neuronal Cell Body
	Molecular Function	Protein Binding Transcription Factor Binding Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	Protein Polyubiquitination Microtubule Cytoskeleton Organization Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission	Cell Death Dopamine Metabolic Process Cellular Protein Metabolic Process Regulation Of Neurotransmitter Secretion Regulation Of Inclusion Body Assembly
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Amyloid fiber formation
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Atrioventricular conduction ( 21041692) Recurrent major depressive disorder ( 29317602)	Chronic kidney disease (end stage renal disease vs. normal eGFR) in type 1 diabetes ( 31537649) Delirium ( 29631748) Depressive symptoms x independent stressful life events interaction (2df test) ( 30718454) Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Mood disorder and prion disease ( 25897833) Response to paclitaxel in ovarian cancer (Caspase 3/7 EC50) ( 27047539)
Interacting Genes		17 interacting genes: C11orf58 CASR ILK MAP3K20 MAP3K7 NUDT21 RPS6KA5 SNCAIP SOD1 SUFU TUBG1 TUBG2 UBE2D2 UBE2E2 UBE2L3 UBE2L6 VCP	19 interacting genes: AGXT C11orf58 GET4 GSK3B NUB1 NUDT21 PIN1 PINK1 PPHLN1 PRKN PTN RNF19A SEPTIN4 SH2D3C SIAH1 SIAH2 SNCA TLE5 UBB
Entrez ID		25897	9627
HPRD ID		06176	04804
Ensembl ID		ENSG00000034677	ENSG00000064692
Uniprot IDs		Q9NV58	B7Z616 B7Z995 Q6L981 Q6L983 Q9Y6H5
PDB IDs			2KES
Enriched GO Terms of Interacting Partners?
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