PLEKHG4 and ARHGEF5

Data Source:
BioGRID (two hybrid)

		PLEKHG4	ARHGEF5
Description		pleckstrin homology and RhoGEF domain containing G4	Rho guanine nucleotide exchange factor 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Junction Cell Projection Cell Periphery
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Lipid Binding
	Biological Process	Regulation Of Catalytic Activity	G Protein-coupled Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Positive Regulation Of JUN Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Regulation Of ERK1 And ERK2 Cascade Activation Of GTPase Activity Positive Regulation Of Protein Import
Pathways			NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Blood protein levels ( 29875488 28240269) Heel bone mineral density ( 28869591) Refractive error ( 32231278)	Breast cancer ( 23535729) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Gut microbiota relative abundance (Parabacteroides) ( 33208821) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		65 interacting genes: A1CF ARHGEF5 ARMC7 BEX2 CCDC120 CCDC187 CDC42 CDKN2C CHIC2 COIL DCUN1D5 DPPA3 DTX2 DUSP13 FAM161A FGD2 GATA3 GCM2 GSTZ1 HCK HOXB9 HOXC8 KRT3 KRT75 MALSU1 MATR3 MDFI METAP1 MSRB3 MTA1 MYEF2 MYOZ1 NATD1 OTX1 PFKFB1 PKP2 PPP1R32 PRPF18 PRPF31 PSMB1 RHOA RIN1 SAXO1 SETD5 SH2D4A SHISA6 SIX1 SMCP SMG9 TBC1D22B TBX18 TEKT3 TENT5D TFAP2D TFG TRIM55 TRIM63 TSSK3 TTC23 USP2 VPS37C ZCCHC14 ZNF148 ZNF319 ZNF648	28 interacting genes: APP ATP13A1 CALCOCO2 CCNE1 CHPF COG6 EFHC2 EPM2AIP1 FKBP8 HSF2BP HSPBAP1 LMO2 LRATD1 MB21D2 MID2 NR4A1 PICK1 PLCG1 PLEKHG4 POLR1C RHOA SEPHS2 SLAIN1 TBC1D13 TCF4 TRIM27 TRIM54 ZRANB1
Entrez ID		25894	7984
HPRD ID		10890	02932
Ensembl ID		ENSG00000196155	ENSG00000050327
Uniprot IDs		A0A024R6X4 Q58EX7	Q12774
PDB IDs
Enriched GO Terms of Interacting Partners?
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