PLEKHG4 and MYOZ1

Data Source:
BioGRID (two hybrid)

		PLEKHG4	MYOZ1
Description		pleckstrin homology and RhoGEF domain containing G4	myozenin 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Nucleus Actin Cytoskeleton Z Disc Pseudopodium
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Actin Binding Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Telethonin Binding FATZ Binding
	Biological Process	Regulation Of Catalytic Activity	Negative Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Myofibril Assembly Negative Regulation Of Phosphoprotein Phosphatase Activity Wound Healing Negative Regulation Of Skeletal Muscle Tissue Regeneration Skeletal Muscle Fiber Adaptation Sarcomere Organization Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 29875488 28240269) Heel bone mineral density ( 28869591) Refractive error ( 32231278)	Atrial fibrillation ( 30061737) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		65 interacting genes: A1CF ARHGEF5 ARMC7 BEX2 CCDC120 CCDC187 CDC42 CDKN2C CHIC2 COIL DCUN1D5 DPPA3 DTX2 DUSP13 FAM161A FGD2 GATA3 GCM2 GSTZ1 HCK HOXB9 HOXC8 KRT3 KRT75 MALSU1 MATR3 MDFI METAP1 MSRB3 MTA1 MYEF2 MYOZ1 NATD1 OTX1 PFKFB1 PKP2 PPP1R32 PRPF18 PRPF31 PSMB1 RHOA RIN1 SAXO1 SETD5 SH2D4A SHISA6 SIX1 SMCP SMG9 TBC1D22B TBX18 TEKT3 TENT5D TFAP2D TFG TRIM55 TRIM63 TSSK3 TTC23 USP2 VPS37C ZCCHC14 ZNF148 ZNF319 ZNF648	40 interacting genes: ACTN1 ACTN2 ACTN3 ACTN4 AKAP8L APP BAG4 BRCA1 CEACAM6 CEP76 CRX EIF3F EXOSC8 FLNA FLNC GOLGA6A GRB2 KRT34 KRT36 KRTAP12-2 LDB3 LHX4 LZTS2 MAGEA11 PFDN5 PLEKHG4 PNKP PNMA1 PRKAA2 TCAP TRAF1 TRIM23 TRIM55 TRIM63 USHBP1 VAC14 VBP1 WASHC3 WWOX YPEL3
Entrez ID		25894	58529
HPRD ID		10890	05725
Ensembl ID		ENSG00000196155	ENSG00000177791
Uniprot IDs		A0A024R6X4 Q58EX7	Q9NP98
PDB IDs
Enriched GO Terms of Interacting Partners?
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