LETMD1 and SH2D1A

Data Source:
BioGRID (two hybrid)

		LETMD1	SH2D1A
Description		LETM1 domain containing 1	SH2 domain containing 1A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Mitochondrion Mitochondrial Outer Membrane Integral Component Of Membrane	Cytoplasm Cytosol
	Molecular Function	Protein Binding Ribosome Binding	Protein Binding
	Biological Process		Adaptive Immune Response Humoral Immune Response Cellular Defense Response Cell-cell Signaling Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases			Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS
Interacting Genes		10 interacting genes: APOC1 APOC2 APOC4 APP CCR1 FBXO7 HCK RHBDD2 SH2D1A TMEM167B	32 interacting genes: AR ARHGEF6 ARHGEF7 ATF3 CCDC74A CD84 DOK1 EGFR ERBB2 ERBB3 ERBB4 FYB1 FYN GRB2 KIT LCK LETMD1 LHX3 LHX4 LY9 MAPK11 MAPK14 MET NCK1 NGEF OLIG1 PTK2 SLAMF1 SLAMF6 SLAMF7 TNK2 ZNHIT1
Entrez ID		25875	4068
HPRD ID		09978	02390
Ensembl ID		ENSG00000050426	ENSG00000183918
Uniprot IDs		A0A384P5D7 F8W1Z2 Q6P1Q0	O60880
PDB IDs			1D1Z 1D4T 1D4W 1KA6 1KA7 1M27
Enriched GO Terms of Interacting Partners?
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