H2BC1 and SET

Data Source:
BioGRID (pull down)

		H2BC1	SET
Description		H2B clustered histone 1	SET nuclear proto-oncogene
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleosome Nucleus Nucleoplasm Extrinsic Component Of Plasma Membrane	Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Molecular_function DNA Binding Histone Binding Protein Heterodimerization Activity	DNA Binding Chromatin Binding Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase Regulator Activity Histone Binding
	Biological Process	Nucleosome Assembly Nucleosome Disassembly Inflammatory Response Protein Ubiquitination Plasminogen Activation Spermatogenesis, Exchange Of Chromosomal Proteins Positive Regulation Of Binding Mononuclear Cell Migration	DNA Replication Nucleosome Assembly Nucleosome Disassembly Viral Process Negative Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Histone Acetylation Regulation Of MRNA Stability Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Transcription, DNA-templated
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation	Condensation of Prophase Chromosomes HuR (ELAVL1) binds and stabilizes mRNA
Drugs
Diseases
GWAS			Axial length ( 24144296) Body mass index ( 26426971) Eating disorders (purging via substances) ( 23568457)
Interacting Genes		8 interacting genes: ANP32B APP CCNA1 DNTTIP2 H2AC20 HDAC3 SET USP44	68 interacting genes: ANP32A APEX1 APP CALM1 CDCA8 CDK5 CDK5R1 CDKN1A CHAF1A CHRM2 CHRM3 ELAVL1 ELF4 ENO1 EP300 ESR1 FAM111B FBXO7 FOS FOXO1 GZMA GZMK H1-1 H2BC1 H3-3A H3-4 H4-16 H4C14 HMGB2 IRF1 JUNB KLF5 KMT2A LGMN MDM2 MEOX2 MTERF1 NME1 NUCB1 NUPR1 PAX6 PIK3CG PPP2CA PPP2R1B PRKAR1A PTEN PTMA RAC1 REPIN1 SDCBP SETBP1 SGO1 SGO2 TAF1A TERF1 TERF2 TERF2IP TEX35 THAP7 TLE5 TREX1 TRIM55 TRIM63 UCHL5 XRCC6 ZNF17 ZNF438 ZNF85
Entrez ID		255626	6418
HPRD ID		11024	09023
Ensembl ID		ENSG00000146047	ENSG00000119335
Uniprot IDs		Q96A08	A0A024R895 A0A0C4DFV9 Q01105 Q5VXV3
PDB IDs		3WKJ 5GSU 5GT3 6BIY	2E50
Enriched GO Terms of Interacting Partners?
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