FYB1 and SH2D1A

Data Source:
HPRD (in vivo, in vitro)

		FYB1	SH2D1A
Description		FYN binding protein 1	SH2 domain containing 1A
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GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Actin Cytoskeleton Cell Junction Protein-containing Complex	Cytoplasm Cytosol
	Molecular Function	Signaling Receptor Binding Protein Binding Lipid Binding Protein-containing Complex Binding	Protein Binding
	Biological Process	Immune Response Integrin-mediated Signaling Pathway Biological_process T Cell Receptor Signaling Pathway Protein Localization To Plasma Membrane	Adaptive Immune Response Humoral Immune Response Cellular Defense Response Cell-cell Signaling Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways		Generation of second messenger molecules Generation of second messenger molecules Signal regulatory protein family interactions	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases			Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS
Interacting Genes		15 interacting genes: BCAR1 CBL CBLB ENAH EVL FASLG FYN LCP2 NCK2 SH2D1A SKAP1 SKAP2 SRC VASP WAS	32 interacting genes: AR ARHGEF6 ARHGEF7 ATF3 CCDC74A CD84 DOK1 EGFR ERBB2 ERBB3 ERBB4 FYB1 FYN GRB2 KIT LCK LETMD1 LHX3 LHX4 LY9 MAPK11 MAPK14 MET NCK1 NGEF OLIG1 PTK2 SLAMF1 SLAMF6 SLAMF7 TNK2 ZNHIT1
Entrez ID		2533	4068
HPRD ID		04107	02390
Ensembl ID		ENSG00000082074	ENSG00000183918
Uniprot IDs		O15117	O60880
PDB IDs		1RI9 2GTJ 2GTO	1D1Z 1D4T 1D4W 1KA6 1KA7 1M27
Enriched GO Terms of Interacting Partners?
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