FRZB and POLA2

Data Source:
BioGRID (two hybrid)

		FRZB	POLA2
Description		frizzled related protein	DNA polymerase alpha 2, accessory subunit
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Membrane	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol
	Molecular Function	Protein Binding Wnt-protein Binding	Molecular_function DNA Binding Protein Binding
	Biological Process	Skeletal System Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Development Neural Crest Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Convergent Extension Involved In Organogenesis Canonical Wnt Signaling Pathway Negative Regulation Of Cartilage Development Somite Development Negative Regulation Of Hepatocyte Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication
Pathways			Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs			Dacarbazine
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Heel bone mineral density ( 30598549 28869591) Neurological blood protein biomarker levels ( 31320639) Night sleep phenotypes ( 27126917) Waist-to-hip circumference ratio (dietary energy interaction) ( 23192594) Working memory ( 31598132)	Acne (severe) ( 24927181) Serum uric acid levels ( 32514006)
Interacting Genes		8 interacting genes: BBS10 CYSRT1 EHF ELF5 PNO1 POLA2 RBX1 SMAD1	33 interacting genes: AKTIP APP ASCC2 ATP5F1C CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SETDB1 SNU13 STK40 ULK2 XPNPEP1
Entrez ID		2487	23649
HPRD ID		07282	10160
Ensembl ID		ENSG00000162998	ENSG00000014138
Uniprot IDs		D9ZGF6 Q92765	Q14181
PDB IDs			2KEB 4E2I 4Y97 5EXR
Enriched GO Terms of Interacting Partners?
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