ARFIP2 and CYTH3

Data Source:
BioGRID (two hybrid)

		ARFIP2	CYTH3
Description		ADP ribosylation factor interacting protein 2	cytohesin 3
Image
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane Cell Cortex Trans-Golgi Network Membrane	Golgi Membrane Ruffle Nucleoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Protein Binding GTP Binding Phospholipid Binding Protein Domain Specific Binding GTP-dependent Protein Binding Small GTPase Binding Identical Protein Binding Cadherin Binding Phosphatidylinositol-4-phosphate Binding Membrane Curvature Sensor Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding
	Biological Process	Intracellular Protein Transport Autophagy Small GTPase Mediated Signal Transduction Lamellipodium Assembly Actin Cytoskeleton Organization Ruffle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Regulation Of ARF Protein Signal Transduction Positive Regulation Of Cell Adhesion Golgi Vesicle Transport Regulation Of Catalytic Activity Establishment Of Epithelial Cell Polarity
Pathways		Retrograde transport at the Trans-Golgi-Network	Intra-Golgi traffic
Drugs			Inositol 1,3,4,5-Tetrakisphosphate Inositol-(1,3,4,5,6)-Pentakisphosphate
Diseases
GWAS		Malaria ( 31844061)	Asthma ( 27611488) Body mass index ( 26426971) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321)
Interacting Genes		61 interacting genes: AGTRAP AKT1 APP ARF1 ARF3 ARF5 ARF6 ARFIP1 ARL1 BLOC1S2 C19orf25 CDKN2A CDR1 CEP63 CMTM5 CYTH3 DGAT2L6 DMAP1 DTNBP1 FADS6 FSD2 GOLGA2 GSG1 HAUS1 HGS ING5 ITGB3BP ITSN1 KRT15 KRT16 LNX1 LY6D MAL2 MIEF1 MIEF2 NDRG4 NRDE2 NUP62 PBX3 PKNOX2 PLP2 PPIF RAC1 RAC2 RAC3 REEP5 REL RND1 SCAMP1 SCAMP5 SDCBP SH3GLB1 SMG9 SNX1 SOCS2 STAT3 SYP TMEM255B TRIM54 TTPA USHBP1	12 interacting genes: ARFIP2 CALCOCO1 CCDC120 CNKSR1 CYTIP FRMD4B IFI35 INAVA IPCEF1 PIK3CA SYCE1 TAMALIN
Entrez ID		23647	9265
HPRD ID		07209	05469
Ensembl ID		ENSG00000132254	ENSG00000008256
Uniprot IDs		A0A087X1E4 B4DUZ3 B4DXH2 P53365	O43739
PDB IDs		1I49 1I4D 1I4L 1I4T 4DCN	4KAX 6U3E 6U3G
Enriched GO Terms of Interacting Partners?
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