ARFIP2 and ARFIP1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid)

		ARFIP2	ARFIP1
Description		ADP ribosylation factor interacting protein 2	ADP ribosylation factor interacting protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane Cell Cortex Trans-Golgi Network Membrane	Golgi Membrane Cytosol Trans-Golgi Network Membrane
	Molecular Function	Protein Binding GTP Binding Phospholipid Binding Protein Domain Specific Binding GTP-dependent Protein Binding Small GTPase Binding Identical Protein Binding Cadherin Binding Phosphatidylinositol-4-phosphate Binding Membrane Curvature Sensor Activity	Protein Binding Phospholipid Binding Protein Domain Specific Binding Phosphatidylinositol-4-phosphate Binding
	Biological Process	Intracellular Protein Transport Autophagy Small GTPase Mediated Signal Transduction Lamellipodium Assembly Actin Cytoskeleton Organization Ruffle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Intracellular Protein Transport Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Protein Secretion Negative Regulation Of Retrograde Transport, Endosome To Golgi
Pathways		Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Malaria ( 31844061)	Blood protein levels ( 29875488) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean platelet volume ( 32888494) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		61 interacting genes: AGTRAP AKT1 APP ARF1 ARF3 ARF5 ARF6 ARFIP1 ARL1 BLOC1S2 C19orf25 CDKN2A CDR1 CEP63 CMTM5 CYTH3 DGAT2L6 DMAP1 DTNBP1 FADS6 FSD2 GOLGA2 GSG1 HAUS1 HGS ING5 ITGB3BP ITSN1 KRT15 KRT16 LNX1 LY6D MAL2 MIEF1 MIEF2 NDRG4 NRDE2 NUP62 PBX3 PKNOX2 PLP2 PPIF RAC1 RAC2 RAC3 REEP5 REL RND1 SCAMP1 SCAMP5 SDCBP SH3GLB1 SMG9 SNX1 SOCS2 STAT3 SYP TMEM255B TRIM54 TTPA USHBP1	19 interacting genes: AFF1 ARF1 ARF3 ARF5 ARFIP2 BSND CMTM5 DESI2 KRT27 KRT33B MAGEA6 RPRM SCAMP1 SFT2D1 SLC2A4 SMIM5 SMPD2 SYNGR3 TNFRSF10D
Entrez ID		23647	27236
HPRD ID		07209	09331
Ensembl ID		ENSG00000132254	ENSG00000164144
Uniprot IDs		A0A087X1E4 B4DUZ3 B4DXH2 P53365	B4E273 B7ZA10 P53367 Q8N8M9
PDB IDs		1I49 1I4D 1I4L 1I4T 4DCN
Enriched GO Terms of Interacting Partners?
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