SUZ12 and MED17

Data Source:
BioGRID (pull down)

		SUZ12	MED17
Description		SUZ12 polycomb repressive complex 2 subunit	mediator complex subunit 17
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Body ESC/E(Z) Complex	Nucleus Nucleoplasm Transcription Regulator Complex Membrane Mediator Complex Core Mediator Complex
	Molecular Function	RNA Polymerase II Transcription Corepressor Binding Protein Binding Chromatin DNA Binding Methylated Histone Binding Histone Methyltransferase Activity Metal Ion Binding Histone Methyltransferase Activity (H3-K27 Specific)	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Nuclear Receptor Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	Spinal Cord Development Response To Retinoic Acid Negative Regulation Of Chemokine Production Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of G0 To G1 Transition Histone H3-K27 Trimethylation	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines SUMOylation of chromatin organization proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference adjusted for BMI ( 25673412)
Interacting Genes		17 interacting genes: AEBP2 BCL11A CDK19 CDK8 CREB1 CTCF EZH2 H1-1 H3-4 LATS2 MED17 MED6 PAXIP1 PJA1 PRDM14 UBE2I WDR77	16 interacting genes: BCL6 CTDP1 ESR1 ESR2 HEMGN HNF4A MED19 MED22 MED30 MED8 PPARGC1A SMARCA4 SREBF1 SUZ12 TP53 USP49
Entrez ID		23512	9440
HPRD ID		06949	04816
Ensembl ID		ENSG00000178691	ENSG00000042429
Uniprot IDs		J3QQW9 Q15022	Q9NVC6
PDB IDs		4W2R 5HYN 5IJ7 5IJ8 5LS6 5WAI 5WAK 5WG6 6B3W 6C23 6C24 6NQ3
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?