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SUZ12 and MED17
Data Source:
BioGRID
(pull down)
SUZ12
MED17
Description
SUZ12 polycomb repressive complex 2 subunit
mediator complex subunit 17
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Nuclear Body
ESC/E(Z) Complex
Nucleus
Nucleoplasm
Transcription Regulator Complex
Membrane
Mediator Complex
Core Mediator Complex
Molecular Function
RNA Polymerase II Transcription Corepressor Binding
Protein Binding
Chromatin DNA Binding
Methylated Histone Binding
Histone Methyltransferase Activity
Metal Ion Binding
Histone Methyltransferase Activity (H3-K27 Specific)
Transcription Coregulator Activity
Transcription Coactivator Activity
Protein Binding
Nuclear Receptor Coactivator Activity
Vitamin D Receptor Binding
Thyroid Hormone Receptor Binding
Biological Process
Spinal Cord Development
Response To Retinoic Acid
Negative Regulation Of Chemokine Production
Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Cell Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Epithelial Cell Proliferation
Negative Regulation Of G0 To G1 Transition
Histone H3-K27 Trimethylation
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Pathways
PRC2 methylates histones and DNA
Oxidative Stress Induced Senescence
PKMTs methylate histone lysines
SUMOylation of chromatin organization proteins
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6
HCMV Early Events
PPARA activates gene expression
Generic Transcription Pathway
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS
High chromosomal aberration frequency (chromosome type) (
31586183
)
Hip circumference adjusted for BMI (
25673412
)
Interacting Genes
17 interacting genes:
AEBP2
BCL11A
CDK19
CDK8
CREB1
CTCF
EZH2
H1-1
H3-4
LATS2
MED17
MED6
PAXIP1
PJA1
PRDM14
UBE2I
WDR77
16 interacting genes:
BCL6
CTDP1
ESR1
ESR2
HEMGN
HNF4A
MED19
MED22
MED30
MED8
PPARGC1A
SMARCA4
SREBF1
SUZ12
TP53
USP49
Entrez ID
23512
9440
HPRD ID
06949
04816
Ensembl ID
ENSG00000178691
ENSG00000042429
Uniprot IDs
J3QQW9
Q15022
Q9NVC6
PDB IDs
4W2R
5HYN
5IJ7
5IJ8
5LS6
5WAI
5WAK
5WG6
6B3W
6C23
6C24
6NQ3
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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