MED17 and USP49

Data Source:
HPRD (in vivo)

		MED17	USP49
Description		mediator complex subunit 17	ubiquitin specific peptidase 49
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Membrane Mediator Complex Core Mediator Complex	Nucleoplasm Cytoplasm
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Nuclear Receptor Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Histone Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter	MRNA Splicing, Via Spliceosome Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein Phosphopantetheinylation Histone H2B Conserved C-terminal Lysine Deubiquitination
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	Ub-specific processing proteases
Drugs
Diseases
GWAS			Cutaneous psoriasis ( 26626624) Mean corpuscular hemoglobin ( 32888494 20139978) Mean corpuscular volume ( 23263863 32888494 20139978 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Red blood cell count ( 32888494 20139978 27863252) Reticulocyte count ( 32888494) Skin aging (microtopography measurement) ( 28502801) Sleep duration (short sleep) ( 30846698)
Interacting Genes		16 interacting genes: BCL6 CTDP1 ESR1 ESR2 HEMGN HNF4A MED19 MED22 MED30 MED8 PPARGC1A SMARCA4 SREBF1 SUZ12 TP53 USP49	12 interacting genes: FKBP5 H2BC21 MED17 MED18 MED8 NAMPT PTCD2 RBCK1 STING1 TP53 TRIM35 ZNF774
Entrez ID		9440	25862
HPRD ID		04816	10075
Ensembl ID		ENSG00000042429	ENSG00000164663
Uniprot IDs		Q9NVC6	Q70CQ1
PDB IDs
Enriched GO Terms of Interacting Partners?
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