SUZ12 and AEBP2

Data Source:
HPRD (in vitro)

		SUZ12	AEBP2
Description		SUZ12 polycomb repressive complex 2 subunit	AE binding protein 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Body ESC/E(Z) Complex	Chromatin Nucleoplasm ESC/E(Z) Complex
	Molecular Function	RNA Polymerase II Transcription Corepressor Binding Protein Binding Chromatin DNA Binding Methylated Histone Binding Histone Methyltransferase Activity Metal Ion Binding Histone Methyltransferase Activity (H3-K27 Specific)	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Metal Ion Binding
	Biological Process	Spinal Cord Development Response To Retinoic Acid Negative Regulation Of Chemokine Production Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of G0 To G1 Transition Histone H3-K27 Trimethylation	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression, Epigenetic
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines SUMOylation of chromatin organization proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events	PRC2 methylates histones and DNA PKMTs methylate histone lysines
Drugs
Diseases
GWAS		High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference adjusted for BMI ( 25673412)	Body size at age 10 ( 32376654) Chronic mountain sickness ( 31417607) Diastolic blood pressure ( 30224653) Diverticular disease ( 30177863) Height ( 28552196) Lung function (FEV1/FVC) ( 30804560) Manganese levels ( 26025379) Obesity-related traits ( 23251661) Opioid use cessation ( 31936517) Pulmonary function ( 21946350) Response to fenofibrate (LDL cholesterol levels) ( 27002377)
Interacting Genes		17 interacting genes: AEBP2 BCL11A CDK19 CDK8 CREB1 CTCF EZH2 H1-1 H3-4 LATS2 MED17 MED6 PAXIP1 PJA1 PRDM14 UBE2I WDR77	18 interacting genes: APP EED H1-1 H1-2 HMBOX1 JMJD6 KRTAP10-8 LDOC1 MDFI PICK1 RALYL RBBP4 SUZ12 THAP1 TRIM55 TRIM63 TSPYL2 ZNF408
Entrez ID		23512	121536
HPRD ID		06949	16477
Ensembl ID		ENSG00000178691	ENSG00000139154
Uniprot IDs		J3QQW9 Q15022	Q6ZN18
PDB IDs		4W2R 5HYN 5IJ7 5IJ8 5LS6 5WAI 5WAK 5WG6 6B3W 6C23 6C24 6NQ3	5WAI 5Y0U 5Y1U 6C23 6C24
Enriched GO Terms of Interacting Partners?
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