FLNB and RAD21

Data Source:
BioGRID (two hybrid)

		FLNB	RAD21
Description		filamin B	RAD21 cohesin complex component
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Cell Cortex Actin Cytoskeleton Integral Component Of Membrane Z Disc Neuron Projection Neuronal Cell Body Extracellular Exosome	Chromosome, Centromeric Region Synaptonemal Complex Spindle Pole Nucleoplasm Chromosome Cytosol Cohesin Complex Membrane Nuclear Matrix Nuclear Mitotic Cohesin Complex Nuclear Meiotic Cohesin Complex
	Molecular Function	RNA Binding Actin Binding Protein Binding Identical Protein Binding Cadherin Binding	Chromatin Binding Protein Binding
	Biological Process	Signal Transduction Muscle Organ Development Actin Cytoskeleton Organization Cell Differentiation	Double-strand Break Repair DNA Recombination Regulation Of Transcription By RNA Polymerase II Apoptotic Process Mitotic Sister Chromatid Cohesion Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Multicellular Organism Development Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Sister Chromatid Cohesion Cell Division Protein Localization To Chromatin Replication-born Double-strand Break Repair Via Sister Chromatid Exchange
Pathways		ISG15 antiviral mechanism	Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases		Spondylocarpotarsal synostosis syndrome FLNB-related disorders, including: ; Atelostogenesis, type I; Boomerang dysplasia; Atelosteogenesis, type III; Larsen syndrome
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) ( 23648065) Eating disorders (purging via substances) ( 23568457) Gut microbiota (bacterial taxa) ( 27723756) Height ( 31217584) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Optic cup area ( 25631615 31798171 28073927) Pulse pressure ( 30578418) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Systemic sclerosis ( 31672989) Vertical cup-disc ratio ( 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White blood cell count ( 32888494)	Menopause (age at onset) ( 29773799)
Interacting Genes		22 interacting genes: ASB2 ATF7IP ERBB2 FBLIM1 FLNA GP1BA HSPB1 ITGB1 ITGB3 ITGB6 MLH1 MYBPC2 NPHP1 PLEKHO1 PSEN1 PSEN2 RAD21 SMURF2 SUMO2 TRIM55 TSC22D2 TSHR	30 interacting genes: CAPN1 CASP7 CFL1 CSTB DISC1 DYNLT1 FHL3 FLNB HNRNPH2 IL7R MSRB2 MT-CO2 NUMA1 PPP1R15A PPP1R15B PTEN RPL10 RPL13 RPL35A SMARCA5 SMC1A SSU72 STAG1 STAG2 SUMO2 TMSB4X TNFRSF14 WAPL WNT2B ZNF80
Entrez ID		2317	5885
HPRD ID		04543	05924
Ensembl ID		ENSG00000136068	ENSG00000164754
Uniprot IDs		O75369	A0A024R9J0 O60216
PDB IDs		2DI8 2DI9 2DIA 2DIB 2DIC 2DJ4 2DLG 2DMB 2DMC 2E9I 2E9J 2EE6 2EE9 2EEA 2EEB 2EEC 2EED 2WA5 2WA6 2WA7 3FER 4B7L 5DCP	4PJU 4PJW 4PK7 6QNX 6RRC 6RRK 6WG3 6WGE
Enriched GO Terms of Interacting Partners?
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