FLNB and FBLIM1

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		FLNB	FBLIM1
Description		filamin B	filamin binding LIM protein 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Cell Cortex Actin Cytoskeleton Integral Component Of Membrane Z Disc Neuron Projection Neuronal Cell Body Extracellular Exosome	Fibrillar Center Stress Fiber Cytoplasm Cytosol Focal Adhesion Cell Junction Cell Periphery
	Molecular Function	RNA Binding Actin Binding Protein Binding Identical Protein Binding Cadherin Binding	Protein Binding Filamin Binding Metal Ion Binding
	Biological Process	Signal Transduction Muscle Organ Development Actin Cytoskeleton Organization Cell Differentiation	Regulation Of Cell Shape Regulation Of Integrin Activation Cell Junction Assembly Cell-cell Adhesion
Pathways		ISG15 antiviral mechanism	Cell-extracellular matrix interactions
Drugs
Diseases		Spondylocarpotarsal synostosis syndrome FLNB-related disorders, including: ; Atelostogenesis, type I; Boomerang dysplasia; Atelosteogenesis, type III; Larsen syndrome
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) ( 23648065) Eating disorders (purging via substances) ( 23568457) Gut microbiota (bacterial taxa) ( 27723756) Height ( 31217584) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Optic cup area ( 25631615 31798171 28073927) Pulse pressure ( 30578418) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Systemic sclerosis ( 31672989) Vertical cup-disc ratio ( 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White blood cell count ( 32888494)	Alcoholic chronic pancreatitis ( 28754779) Cardiac Troponin-T levels ( 23247143) Gut microbiota (bacterial taxa) ( 27723756) Heel bone mineral density ( 30598549)
Interacting Genes		22 interacting genes: ASB2 ATF7IP ERBB2 FBLIM1 FLNA GP1BA HSPB1 ITGB1 ITGB3 ITGB6 MLH1 MYBPC2 NPHP1 PLEKHO1 PSEN1 PSEN2 RAD21 SMURF2 SUMO2 TRIM55 TSC22D2 TSHR	11 interacting genes: ADAT3 C19orf54 CUTA FERMT2 FLNA FLNB H3-5 H3C1 LMO3 SHISA6 TRIM15
Entrez ID		2317	54751
HPRD ID		04543	09669
Ensembl ID		ENSG00000136068	ENSG00000162458
Uniprot IDs		O75369	Q8WUP2
PDB IDs		2DI8 2DI9 2DIA 2DIB 2DIC 2DJ4 2DLG 2DMB 2DMC 2E9I 2E9J 2EE6 2EE9 2EEA 2EEB 2EEC 2EED 2WA5 2WA6 2WA7 3FER 4B7L 5DCP	2K9U 2W0P 4P3W
Enriched GO Terms of Interacting Partners?
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