FLNB and NPHP1

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		FLNB	NPHP1
Description		filamin B	nephrocystin 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Cell Cortex Actin Cytoskeleton Integral Component Of Membrane Z Disc Neuron Projection Neuronal Cell Body Extracellular Exosome	Cytoplasm Cytosol Cytoskeleton Cell-cell Junction Adherens Junction Bicellular Tight Junction Cilium Membrane Motile Cilium Photoreceptor Connecting Cilium
	Molecular Function	RNA Binding Actin Binding Protein Binding Identical Protein Binding Cadherin Binding	Structural Molecule Activity Protein Binding
	Biological Process	Signal Transduction Muscle Organ Development Actin Cytoskeleton Organization Cell Differentiation	Signal Transduction Excretion Visual Behavior Cell Projection Organization Actin Cytoskeleton Organization Spermatid Differentiation Retina Development In Camera-type Eye Protein Localization Involved In Establishment Of Planar Polarity Ciliary Basal Body-plasma Membrane Docking Cell-cell Adhesion Positive Regulation Of Bicellular Tight Junction Assembly
Pathways		ISG15 antiviral mechanism	Anchoring of the basal body to the plasma membrane
Drugs
Diseases		Spondylocarpotarsal synostosis syndrome FLNB-related disorders, including: ; Atelostogenesis, type I; Boomerang dysplasia; Atelosteogenesis, type III; Larsen syndrome	Joubert syndrome Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2) Senior-Loken syndrome
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) ( 23648065) Eating disorders (purging via substances) ( 23568457) Gut microbiota (bacterial taxa) ( 27723756) Height ( 31217584) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Optic cup area ( 25631615 31798171 28073927) Pulse pressure ( 30578418) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Systemic sclerosis ( 31672989) Vertical cup-disc ratio ( 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White blood cell count ( 32888494)
Interacting Genes		22 interacting genes: ASB2 ATF7IP ERBB2 FBLIM1 FLNA GP1BA HSPB1 ITGB1 ITGB3 ITGB6 MLH1 MYBPC2 NPHP1 PLEKHO1 PSEN1 PSEN2 RAD21 SMURF2 SUMO2 TRIM55 TSC22D2 TSHR	16 interacting genes: ADAM15 ARHGAP32 BCAR1 FBXO7 FLNA FLNB FLNC INVS KHDRBS1 NPHP3 NPHP4 PAK2 PTK2B TNK2 TUBB UBQLN4
Entrez ID		2317	4867
HPRD ID		04543	09524
Ensembl ID		ENSG00000136068	ENSG00000144061
Uniprot IDs		O75369	C9JNM7 O15259
PDB IDs		2DI8 2DI9 2DIA 2DIB 2DIC 2DJ4 2DLG 2DMB 2DMC 2E9I 2E9J 2EE6 2EE9 2EEA 2EEB 2EEC 2EED 2WA5 2WA6 2WA7 3FER 4B7L 5DCP	1S1N 6O1Q
Enriched GO Terms of Interacting Partners?
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