FLII and CARM1

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		FLII	CARM1
Description		FLII actin remodeling protein	coactivator associated arginine methyltransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Brush Border Focal Adhesion Actin Cytoskeleton Centriolar Satellite	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Actin Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Actin Filament Binding	Transcription Regulatory Region Sequence-specific DNA Binding Transcription Coactivator Activity Protein Binding Beta-catenin Binding Protein Methyltransferase Activity Histone-arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Nuclear Receptor Coactivator Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity (H3-R17 Specific) Histone Methyltransferase Activity Lysine-acetylated Histone Binding
	Biological Process	Multicellular Organism Development Actin Polymerization Or Depolymerization Myofibril Assembly Actin Filament Severing Barbed-end Actin Filament Capping	Regulation Of Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Aging Positive Regulation Of Cell Population Proliferation Viral Process Histone Methylation Regulation Of Lipid Metabolic Process Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Regulation Of Intracellular Estrogen Receptor Signaling Pathway Histone H3-R2 Methylation Histone H3-R17 Methylation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Response To CAMP Regulation Of MRNA Binding Negative Regulation Of Dendrite Development
Pathways			RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) RMTs methylate histone arginines Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Estrogen-dependent gene expression
Drugs
Diseases
GWAS			C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624)
Interacting Genes		13 interacting genes: ACTB ACTL6A CARM1 DLST ESR1 GRIP1 LRRFIP1 LRRFIP2 MYD88 NCOA2 OPTN PRMT1 TRAIP	33 interacting genes: AXIN1 CREBBP CTNNB1 DAXX DNAJA3 DZIP3 ELAVL1 EP300 FLII FOS GRIP1 H3-3A H3-3B H3C1 MALT1 MEF2D MYOD1 MYOG NCOA1 NCOA2 NUDT21 PABPC1 PABPN1 PRMT8 PYGO1 QKI RABGAP1 RELA SMARCA4 SPAG8 SRCAP TP53 UBE2I
Entrez ID		2314	10498
HPRD ID		02647	09158
Ensembl ID		ENSG00000177731	ENSG00000142453
Uniprot IDs		Q13045	Q86X55
PDB IDs			2Y1W 2Y1X 4IKP 5DWQ 5DX0 5DX1 5DX8 5DXA 5DXJ 5U4X 6ARJ 6ARV 6D2L 6DVR 6IZQ 6S70 6S71 6S74 6S77 6S79 6S7A 6S7B 6S7C
Enriched GO Terms of Interacting Partners?
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