FLII and LRRFIP1

Data Source:
HPRD (in vitro)

		FLII	LRRFIP1
Description		FLII actin remodeling protein	LRR binding FLII interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Brush Border Focal Adhesion Actin Cytoskeleton Centriolar Satellite	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane
	Molecular Function	Actin Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Actin Filament Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Double-stranded RNA Binding Protein Binding Protein Homodimerization Activity Cadherin Binding
	Biological Process	Multicellular Organism Development Actin Polymerization Or Depolymerization Myofibril Assembly Actin Filament Severing Barbed-end Actin Filament Capping	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Type I Interferon Production Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways			Signaling by cytosolic FGFR1 fusion mutants LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Signaling by FGFR1 in disease
Drugs
Diseases
GWAS			Adiposity ( 23505185) Apolipoprotein A1 levels ( 32203549) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Longevity ( 30294719)
Interacting Genes		13 interacting genes: ACTB ACTL6A CARM1 DLST ESR1 GRIP1 LRRFIP1 LRRFIP2 MYD88 NCOA2 OPTN PRMT1 TRAIP	6 interacting genes: CEP44 FBXO7 FLII MED4 SERPINB5 SH2D2A
Entrez ID		2314	9208
HPRD ID		02647	04460
Ensembl ID		ENSG00000177731	ENSG00000124831
Uniprot IDs		Q13045	A0A0F7NGI8 B4DPC0 Q32MZ4
PDB IDs			4H22
Enriched GO Terms of Interacting Partners?
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