CARM1 and MALT1

Data Source:
BioGRID (two hybrid)

		CARM1	MALT1
Description		coactivator associated arginine methyltransferase 1	MALT1 paracaspase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Fibrillar Center Polkadots Nucleus Cytoplasm Cytosol CBM Complex Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Transcription Coactivator Activity Protein Binding Beta-catenin Binding Protein Methyltransferase Activity Histone-arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Nuclear Receptor Coactivator Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity (H3-R17 Specific) Histone Methyltransferase Activity Lysine-acetylated Histone Binding	Protease Binding Cysteine-type Endopeptidase Activity Ubiquitin-protein Transferase Activity Protein Binding Peptidase Activity Kinase Activator Activity Identical Protein Binding Protein Self-association
	Biological Process	Regulation Of Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Aging Positive Regulation Of Cell Population Proliferation Viral Process Histone Methylation Regulation Of Lipid Metabolic Process Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Regulation Of Intracellular Estrogen Receptor Signaling Pathway Histone H3-R2 Methylation Histone H3-R17 Methylation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Response To CAMP Regulation Of MRNA Binding Negative Regulation Of Dendrite Development	B-1 B Cell Differentiation Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of T Cell Cytokine Production Proteolysis Defense Response Activation Of NF-kappaB-inducing Kinase Activity Response To Fungus Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-2 Production Fc-epsilon Receptor Signaling Pathway T Cell Proliferation B Cell Activation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Nuclear Export Positive Regulation Of T-helper 17 Cell Differentiation
Pathways		RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) RMTs methylate histone arginines Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Estrogen-dependent gene expression	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling CLEC7A/inflammasome pathway
Drugs
Diseases
GWAS		C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624)	Metabolite levels ( 23823483) Multiple sclerosis ( 31604244 21833088)
Interacting Genes		33 interacting genes: AXIN1 CREBBP CTNNB1 DAXX DNAJA3 DZIP3 ELAVL1 EP300 FLII FOS GRIP1 H3-3A H3-3B H3C1 MALT1 MEF2D MYOD1 MYOG NCOA1 NCOA2 NUDT21 PABPC1 PABPN1 PRMT8 PYGO1 QKI RABGAP1 RELA SMARCA4 SPAG8 SRCAP TP53 UBE2I	16 interacting genes: BCL10 CARM1 FEM1A FEM1C KDM1A PRMT6 RBCK1 RELB SQSTM1 SUV39H1 TRAF2 TRAF6 UBC UBE2N UBE2V2 USP2
Entrez ID		10498	10892
HPRD ID		09158	06892
Ensembl ID		ENSG00000142453	ENSG00000172175
Uniprot IDs		Q86X55	A8K5S1 Q9UDY8
PDB IDs		2Y1W 2Y1X 4IKP 5DWQ 5DX0 5DX1 5DX8 5DXA 5DXJ 5U4X 6ARJ 6ARV 6D2L 6DVR 6IZQ 6S70 6S71 6S74 6S77 6S79 6S7A 6S7B 6S7C	2G7R 3BFO 3K0W 3UO8 3UOA 3V4O 3V55 4I1P 4I1R 6F7I 6GK2 6H4A 6YN8 6YN9
Enriched GO Terms of Interacting Partners?
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