SPEN and RIDA

Data Source:
BioGRID (two hybrid)

		SPEN	RIDA
Description		spen family transcriptional repressor	reactive intermediate imine deaminase A homolog
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Repressor Complex Extracellular Exosome	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Peroxisome Cytosol Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Factor Binding Nucleic Acid Binding DNA Binding Transcription Corepressor Activity RNA Binding Protein Binding	RNA Binding MRNA Binding Protein Binding Endoribonuclease Activity, Producing 3'-phosphomonoesters Deaminase Activity 2-iminobutanoate/2-iminopropanoate Deaminase
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MRNA Splicing, Via Spliceosome Notch Signaling Pathway Viral Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis	MRNA Catabolic Process Negative Regulation Of Translation L-threonine Catabolic Process To Glycine MRNA Destabilization RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Organonitrogen Compound Catabolic Process
Pathways			Threonine catabolism
Drugs
Diseases
GWAS		Erectile dysfunction ( 30583798) Heel bone mineral density ( 28869591) Hemoglobin levels ( 32327693)
Interacting Genes		22 interacting genes: ATXN1 CLK1 CTBP1 DLX5 HDAC1 HDAC2 MBD3 MSX2 MTA2 NCOR1 NCOR2 PPARD RARA RBBP4 RBPJ RIDA RUNX1 RUNX1T1 SERTAD1 SOX9 SRPK2 UBE2L6	10 interacting genes: BANP DEAF1 HIVEP1 HPD MDM2 MT-CO2 SERPINA5 SPEN TMEM176A TRIB3
Entrez ID		23013	10247
HPRD ID		10230	03924
Ensembl ID		ENSG00000065526	ENSG00000132541
Uniprot IDs		Q96T58	A0A024R9H2 P52758
PDB IDs		1OW1 2RT5 4P6Q	1ONI
Enriched GO Terms of Interacting Partners?
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