SPEN and DLX5

Data Source:
HPRD (in vitro)

		SPEN	DLX5
Description		spen family transcriptional repressor	distal-less homeobox 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Repressor Complex Extracellular Exosome	Chromatin Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Factor Binding Nucleic Acid Binding DNA Binding Transcription Corepressor Activity RNA Binding Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MRNA Splicing, Via Spliceosome Notch Signaling Pathway Viral Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis	Skeletal System Development Osteoblast Differentiation Endochondral Ossification Regulation Of Transcription By RNA Polymerase II Nervous System Development Cell Population Proliferation Embryo Development Olfactory Bulb Interneuron Differentiation Cell Differentiation Embryonic Limb Morphogenesis BMP Signaling Pathway Epithelial Cell Differentiation Inner Ear Morphogenesis Positive Regulation Of Transcription, DNA-templated Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Roof Of Mouth Development Olfactory Pit Development Face Morphogenesis Cellular Response To BMP Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Interneuron Axon Guidance Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways			Regulation of RUNX2 expression and activity
Drugs
Diseases
GWAS		Erectile dysfunction ( 30583798) Heel bone mineral density ( 28869591) Hemoglobin levels ( 32327693)	Heel bone mineral density ( 30598549 28869591) Morning vs. evening chronotype ( 26835600)
Interacting Genes		22 interacting genes: ATXN1 CLK1 CTBP1 DLX5 HDAC1 HDAC2 MBD3 MSX2 MTA2 NCOR1 NCOR2 PPARD RARA RBBP4 RBPJ RIDA RUNX1 RUNX1T1 SERTAD1 SOX9 SRPK2 UBE2L6	9 interacting genes: DLX2 HOXC8 MAGED1 MSX1 MSX2 NCOA2 SOX10 SOX8 SPEN
Entrez ID		23013	1749
HPRD ID		10230	02492
Ensembl ID		ENSG00000065526	ENSG00000105880
Uniprot IDs		Q96T58	P56178 Q53Y73
PDB IDs		1OW1 2RT5 4P6Q	2DJN 4RDU
Enriched GO Terms of Interacting Partners?
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