RIDA and SPEN

Data Source:
BioGRID (two hybrid)

		RIDA	SPEN
Description		reactive intermediate imine deaminase A homolog	spen family transcriptional repressor
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Peroxisome Cytosol Extracellular Exosome	Nucleus Nucleoplasm Transcription Repressor Complex Extracellular Exosome
	Molecular Function	RNA Binding MRNA Binding Protein Binding Endoribonuclease Activity, Producing 3'-phosphomonoesters Deaminase Activity 2-iminobutanoate/2-iminopropanoate Deaminase	RNA Polymerase II Transcription Factor Binding Nucleic Acid Binding DNA Binding Transcription Corepressor Activity RNA Binding Protein Binding
	Biological Process	MRNA Catabolic Process Negative Regulation Of Translation L-threonine Catabolic Process To Glycine MRNA Destabilization RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Organonitrogen Compound Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II MRNA Splicing, Via Spliceosome Notch Signaling Pathway Viral Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis
Pathways		Threonine catabolism
Drugs
Diseases
GWAS			Erectile dysfunction ( 30583798) Heel bone mineral density ( 28869591) Hemoglobin levels ( 32327693)
Interacting Genes		10 interacting genes: BANP DEAF1 HIVEP1 HPD MDM2 MT-CO2 SERPINA5 SPEN TMEM176A TRIB3	22 interacting genes: ATXN1 CLK1 CTBP1 DLX5 HDAC1 HDAC2 MBD3 MSX2 MTA2 NCOR1 NCOR2 PPARD RARA RBBP4 RBPJ RIDA RUNX1 RUNX1T1 SERTAD1 SOX9 SRPK2 UBE2L6
Entrez ID		10247	23013
HPRD ID		03924	10230
Ensembl ID		ENSG00000132541	ENSG00000065526
Uniprot IDs		A0A024R9H2 P52758	Q96T58
PDB IDs		1ONI	1OW1 2RT5 4P6Q
Enriched GO Terms of Interacting Partners?
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