FAN1 and CCR1

Data Source:
BioGRID (two hybrid)

		FAN1	CCR1
Description		FANCD2 and FANCI associated nuclease 1	C-C motif chemokine receptor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Intercellular Bridge	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Magnesium Ion Binding Phosphodiesterase I Activity Protein Binding 5'-3' Exonuclease Activity 5'-flap Endonuclease Activity Flap-structured DNA Binding Ubiquitin-dependent Protein Binding	Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 5 Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision Interstrand Cross-link Repair	Dendritic Cell Chemotaxis Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cell Adhesion Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Response To Wounding Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Calcium Ion Transport Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis
Pathways		Fanconi Anemia Pathway	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs
Diseases
GWAS		Huntington's disease (age at onset) ( 29750799) Huntington's disease progression ( 28642124)	Arthritis (juvenile idiopathic) ( 33106285) Behcet's disease ( 23291587) Celiac disease ( 22057235 20190752 30572963 18311140) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 26192919) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Narcolepsy with cataplexy ( 25986216) Ulcerative colitis ( 26192919 28067908)
Interacting Genes		4 interacting genes: CCR1 MLH1 PCNA UBC	29 interacting genes: CCL14 CCL15 CCL16 CCL2 CCL23 CCL26 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CD74 CREB3 FAN1 GNA14 GRAMD1A JAK1 LETMD1 MBP PLP2 PRNP QSOX1 STAT1 STAT3 TMEFF1 TMX1 TPST1 TPST2
Entrez ID		22909	1230
HPRD ID		17205	03101
Ensembl ID		ENSG00000198690	ENSG00000163823
Uniprot IDs		Q9Y2M0	P32246 Q5U003
PDB IDs		4REA 4REB 4REC 4RI8 4RI9 4RIA 4RIB 4RIC 4RID 4RY3	1Y5D
Enriched GO Terms of Interacting Partners?
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