FKBP5 and IKBKE

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		FKBP5	IKBKE
Description		FKBP prolyl isomerase 5	inhibitor of nuclear factor kappa B kinase subunit epsilon
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane PML Body Mitochondrial Membrane
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding FK506 Binding Heat Shock Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Protein Phosphatase Binding Ubiquitin Protein Ligase Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization Protein Folding Response To Bacterium Chaperone-mediated Protein Folding	Protein Phosphorylation Immune Response I-kappaB Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Lipid Storage Viral Process Peptidyl-serine Phosphorylation Negative Regulation Of Type I Interferon Production Response To Type I Interferon Response To Interferon-beta TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Virus
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR) ESR-mediated signaling MECP2 regulates neuronal receptors and channels	SUMOylation of immune response proteins TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs			Fostamatinib
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Birth weight ( 31043758) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Eosinophil counts ( 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Offspring birth weight ( 31043758) White blood cell count ( 27863252)	Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Psoriasis ( 28537254) Systemic lupus erythematosus ( 27399966)
Interacting Genes		14 interacting genes: APP CHUK ESR1 FES GLMN HSF1 HSP90AA1 IKBKE MAPT MCMBP NR2C2 PGR STIP1 USP49	22 interacting genes: AZI2 BIRC2 BIRC3 CDC37 CHUK CYLD DDX3X FKBP5 HSP90AA1 HSP90AB1 IRF3 IRF5 KTN1 MBP NFKBIA RELA RIPK1 SIKE1 TANK TICAM1 TRIM27 XIAP
Entrez ID		2289	9641
HPRD ID		04019	05442
Ensembl ID		ENSG00000096060	ENSG00000263528
Uniprot IDs		Q13451 Q2TA84	A0A075B7B4 Q14164
PDB IDs		1KT0 3O5D 3O5E 3O5F 3O5G 3O5I 3O5J 3O5K 3O5L 3O5M 3O5O 3O5P 3O5Q 3O5R 4DRH 4DRI 4DRK 4DRM 4DRN 4DRO 4DRP 4DRQ 4JFI 4JFJ 4JFK 4JFL 4JFM 4R0X 4TW6 4TW7 4TX0 4W9O 4W9P 4W9Q 5BXJ 5DIT 5DIU 5DIV 5NJX 5OBK 5OMP 6SAF 6TX4 6TX5 6TX6 6TX7 6TX8 6TX9 6TXX
Enriched GO Terms of Interacting Partners?
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