FKBP5 and PGR

Data Source:
HPRD (in vivo)

		FKBP5	PGR
Description		FKBP prolyl isomerase 5	progesterone receptor
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane Extracellular Exosome	Chromatin Nucleoplasm Mitochondrial Outer Membrane Cytosol
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding FK506 Binding Heat Shock Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Steroid Hormone Receptor Activity Nuclear Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Enzyme Binding Identical Protein Binding ATPase Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization Protein Folding Response To Bacterium Chaperone-mediated Protein Folding	Ovulation From Ovarian Follicle Epithelial Cell Maturation Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Cell-cell Signaling Negative Regulation Of Gene Expression Intracellular Steroid Hormone Receptor Signaling Pathway Paracrine Signaling Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Regulation Of Epithelial Cell Proliferation Progesterone Receptor Signaling Pathway Tertiary Branching Involved In Mammary Gland Duct Morphogenesis
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR) ESR-mediated signaling MECP2 regulates neuronal receptors and channels	Nuclear signaling by ERBB4 HSP90 chaperone cycle for steroid hormone receptors (SHR) Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Estrogen-dependent gene expression
Drugs			Etonogestrel Desogestrel Megestrol acetate Levonorgestrel Dydrogesterone Progesterone Spironolactone Lindane Fluticasone propionate Medroxyprogesterone acetate Mitotane Norethisterone Mometasone Ethynodiol diacetate Mifepristone Norgestimate Drospirenone Danazol Oxybenzone Allylestrenol Phthalic Acid Metribolone Tanaproget Telapristone acetate Asoprisnil Norelgestromin Gestodene Hydroxyprogesterone caproate Ulipristal Fluticasone furoate Dienogest Medrogestone Norgestrel Homosalate Enzacamene Gestrinone Darolutamide Demegestone Fluticasone Mometasone furoate Segesterone acetate
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Birth weight ( 31043758) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Eosinophil counts ( 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Offspring birth weight ( 31043758) White blood cell count ( 27863252)	Diastolic blood pressure ( 30224653) Length of menstrual cycle ( 30202859) Menarche (age at onset) ( 25231870) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		14 interacting genes: APP CHUK ESR1 FES GLMN HSF1 HSP90AA1 IKBKE MAPT MCMBP NR2C2 PGR STIP1 USP49	53 interacting genes: ANP32A APEX2 ARID1A BATF3 BCAS2 BMI1 BRCA1 CCNA1 CCNA2 CDC25B CDK2 COPS5 CSNK2A1 CUEDC2 DAP3 DDX54 DNAJA1 ESR1 FKBP5 HMGB1 HMGB2 HSPA1A JDP2 KAT2B KLF9 NCOA1 NCOA3 NR0B1 PIAS1 PIAS2 PIAS3 POU2F1 POU2F2 PRKDC PRMT2 RBM23 RBM39 RELA RNF4 SGTA SMARCD1 SMARCE1 SNW1 SORBS1 SRC TAF1B TDG TRIM24 UBE3A UBR5 XRCC5 XRCC6 ZBTB17
Entrez ID		2289	5241
HPRD ID		04019	07077
Ensembl ID		ENSG00000096060	ENSG00000082175
Uniprot IDs		Q13451 Q2TA84	P06401
PDB IDs		1KT0 3O5D 3O5E 3O5F 3O5G 3O5I 3O5J 3O5K 3O5L 3O5M 3O5O 3O5P 3O5Q 3O5R 4DRH 4DRI 4DRK 4DRM 4DRN 4DRO 4DRP 4DRQ 4JFI 4JFJ 4JFK 4JFL 4JFM 4R0X 4TW6 4TW7 4TX0 4W9O 4W9P 4W9Q 5BXJ 5DIT 5DIU 5DIV 5NJX 5OBK 5OMP 6SAF 6TX4 6TX5 6TX6 6TX7 6TX8 6TX9 6TXX	1A28 1E3K 1SQN 1SR7 1ZUC 2C7A 2OVH 2OVM 2W8Y 3D90 3G8O 3HQ5 3KBA 3ZR7 3ZRA 3ZRB 4A2J 4APU 4OAR 5CC0
Enriched GO Terms of Interacting Partners?
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