IKBKE and AZI2

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		IKBKE	AZI2
Description		inhibitor of nuclear factor kappa B kinase subunit epsilon	5-azacytidine induced 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane PML Body Mitochondrial Membrane	Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Protein Phosphatase Binding Ubiquitin Protein Ligase Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Protein Binding
	Biological Process	Protein Phosphorylation Immune Response I-kappaB Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Lipid Storage Viral Process Peptidyl-serine Phosphorylation Negative Regulation Of Type I Interferon Production Response To Type I Interferon Response To Interferon-beta TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Virus	Mitotic Cell Cycle I-kappaB Kinase/NF-kappaB Signaling Viral Process T Cell Activation Dendritic Cell Proliferation Dendritic Cell Differentiation
Pathways		SUMOylation of immune response proteins TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs		Fostamatinib
Diseases
GWAS		Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Psoriasis ( 28537254) Systemic lupus erythematosus ( 27399966)	Cognitive decline (age-related) ( 28078323)
Interacting Genes		22 interacting genes: AZI2 BIRC2 BIRC3 CDC37 CHUK CYLD DDX3X FKBP5 HSP90AA1 HSP90AB1 IRF3 IRF5 KTN1 MBP NFKBIA RELA RIPK1 SIKE1 TANK TICAM1 TRIM27 XIAP	13 interacting genes: APBA3 FAM107A IKBKE MIB1 MTPAP N4BP1 RB1CC1 RNF31 TAX1BP1 TBK1 TICAM1 TRAF3 TXLNA
Entrez ID		9641	64343
HPRD ID		05442	10577
Ensembl ID		ENSG00000263528	ENSG00000163512
Uniprot IDs		A0A075B7B4 Q14164	Q9H6S1
PDB IDs			5EP6 5Z7G 5Z7L
Enriched GO Terms of Interacting Partners?
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