ANKRD6 and AXIN2

Data Source:
HPRD (two hybrid, in vivo)

		ANKRD6	AXIN2
Description		ankyrin repeat domain 6	axin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm Centrosome Cytosol Beta-catenin Destruction Complex
	Molecular Function		Protein Binding Beta-catenin Binding Enzyme Binding Ubiquitin Protein Ligase Binding I-SMAD Binding
	Biological Process	Positive Regulation Of JNK Cascade Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway	Somitogenesis Positive Regulation Of Protein Phosphorylation Intramembranous Ossification Secondary Heart Field Specification Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Death Wnt Signaling Pathway Bone Mineralization Regulation Of Mismatch Repair Cellular Protein Localization Odontogenesis Maintenance Of DNA Repeat Elements Negative Regulation Of Osteoblast Differentiation MRNA Stabilization Regulation Of Chondrocyte Development Regulation Of Centromeric Sister Chromatid Cohesion Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly
Pathways			TCF dependent signaling in response to WNT Binding of TCF/LEF:CTNNB1 to target gene promoters Degradation of AXIN Ub-specific processing proteases
Drugs
Diseases			Tooth agenesis; Hypodontia Oligodontia-colorectal cancer syndrome
GWAS		Bipolar disorder ( 25827505) Coronary artery disease ( 29212778 33020668) Knee osteoarthritis ( 28916551) Metabolite levels (Pyroglutamine) ( 23934736) vWF and FVIII levels ( 21810271) Waist-hip ratio ( 28552196)	Blond vs. brown/black hair color ( 30531825) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Refractive error ( 32231278)
Interacting Genes		2 interacting genes: AXIN2 CSNK1E	52 interacting genes: AMOT ANKRD6 AP1M1 APC APC2 BARD1 BTRC BYSL C2orf68 CAPN7 CCDC112 CHIC2 CSNK1E CTAG2 CTNNB1 CWF19L2 ELOA FAM161A FBP1 FBP2 GSK3B HEMGN HOXB5 KCNK12 KIFC3 KRTAP10-10 KRTAP10-8 KRTAP4-5 KRTAP9-2 LNX1 MCRS1 PPP2R5A PRDX1 PSMB2 RANGAP1 SCNM1 SMAD1 SMAD3 SMAD7 STX11 TCEA2 TCEANC TGFB1 TOP3B TSGA10 TXLNA TXLNB ZNF124 ZNF189 ZNF417 ZNF587 ZNF648
Entrez ID		22881	8313
HPRD ID		09798	04935
Ensembl ID		ENSG00000135299	ENSG00000168646
Uniprot IDs		B7Z3D2 Q9Y2G4	E7ES00 Q9Y2T1
PDB IDs
Enriched GO Terms of Interacting Partners?
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