JMJD1C and RNF8

Data Source:
BioGRID (pull down, affinity chromatography technology)

		JMJD1C	RNF8
Description		jumonji domain containing 1C	ring finger protein 8
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleoplasm	Ubiquitin Ligase Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Midbody Site Of Double-strand Break
	Molecular Function	Transcription Coregulator Activity Protein Binding Chromatin DNA Binding Histone Demethylase Activity (H3-K9 Specific) Metal Ion Binding Thyroid Hormone Receptor Binding Dioxygenase Activity	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Blood Coagulation Histone H3-K9 Demethylation	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Cell Cycle Spermatid Development Response To Ionizing Radiation Viral Process Protein Ubiquitination Histone H2A Ubiquitination Histone H2B Ubiquitination Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Spermatogenesis, Exchange Of Chromosomal Proteins Interstrand Cross-link Repair Histone Exchange Isotype Switching Positive Regulation Of DNA Repair Cell Division Protein Autoubiquitination Protein K63-linked Ubiquitination Histone H2A K63-linked Ubiquitination Protein K48-linked Ubiquitination
Pathways		Factors involved in megakaryocyte development and platelet production	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Adult body size ( 32376654) Androgen levels ( 22936694) Apolipoprotein A1 levels ( 32203549) Arthritis (juvenile idiopathic) ( 22354554) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) Basophil percentage of granulocytes ( 27863252) Blood protein levels ( 29875488) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) CXCL5 levels ( 25147954) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Educational attainment ( 25201988) Eosinophil percentage of white cells ( 32888494) Fasting plasma glucose ( 31170924) FEV1 ( 30804560) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Gallstone disease ( 30504769) General cognitive ability ( 29844566) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 31928498) High light scatter reticulocyte count ( 27863252) Household income (MTAG) ( 31844048) Immature fraction of reticulocytes ( 32888494 27863252) Inflammatory biomarkers (multivariate analysis) ( 33110245) Insulin-related traits (multivariate analysis) ( 32002517) Intelligence (MTAG) ( 29326435) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FEV1) ( 30061609) Lung function (FEV1/FVC) ( 30061609) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 22139419 24026423 19820697 31194788 32888494 27863252 28031487) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Metabolite levels ( 23823483) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Platelet aggregation ( 20526338 29185836) Platelet count ( 26805783 22139419 24026423 23263863 32888494 22423221 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) Prothrombin time ( 29403010) Schizophrenia ( 28991256) Serum alkaline phosphatase levels ( 31666285 29403010) Sex hormone-binding globulin levels ( 22829776) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total bilirubin levels ( 29403010) Triglyceride levels ( 32203549 28334899 32154731 29403010 31928498) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068 25961943 20686565) Type 2 diabetes ( 28406950 32499647) Urate levels ( 31578528) Vascular endothelial growth factor levels ( 26910538 27989323) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) White blood cell count ( 27863252)	Acne (severe) ( 24927181) Restless legs syndrome ( 29029846)
Interacting Genes		14 interacting genes: AR ESR2 GADD45A MT2A MYOM2 NUDT21 PPARG PSMC1 RNF168 RNF8 RXRA SRPK2 THRB TK1	76 interacting genes: AMOTL2 BLM C2CD6 CALCOCO1 CCDC14 CCDC50 CCDC85B CEP44 CEP85 CHD4 CHEK2 CLK2 CLK3 DNM2 DNTTIP2 EPN2 EPN3 EXOSC2 FAM9B FSD2 GPRASP2 H2AC20 H2AX H2BC21 H2BC3 H3-3B HOMEZ JMJD1C KDM4A KIF24 KRTAP10-1 KRTAP10-8 KRTAP9-2 KRTAP9-8 LMO4 MAD1L1 MAGED1 MAPK1 MDC1 MDM2 PCNA PCYT1A PGRMC2 PICK1 PNMA2 POLD4 PSMB1 RBFOX2 RXRA RYBP SCN3B SEPTIN3 SH3GL3 STX11 SUMO2 SUMO3 TMEM79 TNIP1 TOMM20L TRIM29 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V2 UBE2W VCP WASL YEATS4 ZBTB10 ZNF346 ZNF496
Entrez ID		221037	9025
HPRD ID		05141	11521
Ensembl ID		ENSG00000171988	ENSG00000112130
Uniprot IDs		B7ZLC8 Q15652	O76064
PDB IDs		2YPD 5FZO	2CSW 2PIE 4AYC 4ORH 4WHV
Enriched GO Terms of Interacting Partners?
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