JMJD1C and MYOM2

Data Source:
BioGRID (two hybrid)

		JMJD1C	MYOM2
Description		jumonji domain containing 1C	myomesin 2
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleoplasm	Mitochondrion M Band Myosin Filament
	Molecular Function	Transcription Coregulator Activity Protein Binding Chromatin DNA Binding Histone Demethylase Activity (H3-K9 Specific) Metal Ion Binding Thyroid Hormone Receptor Binding Dioxygenase Activity	Protein Binding Structural Constituent Of Muscle Kinase Binding Actin Filament Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Blood Coagulation Histone H3-K9 Demethylation	Extraocular Skeletal Muscle Development Muscle Contraction
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Adult body size ( 32376654) Androgen levels ( 22936694) Apolipoprotein A1 levels ( 32203549) Arthritis (juvenile idiopathic) ( 22354554) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) Basophil percentage of granulocytes ( 27863252) Blood protein levels ( 29875488) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) CXCL5 levels ( 25147954) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Educational attainment ( 25201988) Eosinophil percentage of white cells ( 32888494) Fasting plasma glucose ( 31170924) FEV1 ( 30804560) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Gallstone disease ( 30504769) General cognitive ability ( 29844566) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 31928498) High light scatter reticulocyte count ( 27863252) Household income (MTAG) ( 31844048) Immature fraction of reticulocytes ( 32888494 27863252) Inflammatory biomarkers (multivariate analysis) ( 33110245) Insulin-related traits (multivariate analysis) ( 32002517) Intelligence (MTAG) ( 29326435) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FEV1) ( 30061609) Lung function (FEV1/FVC) ( 30061609) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 22139419 24026423 19820697 31194788 32888494 27863252 28031487) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Metabolite levels ( 23823483) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Platelet aggregation ( 20526338 29185836) Platelet count ( 26805783 22139419 24026423 23263863 32888494 22423221 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) Prothrombin time ( 29403010) Schizophrenia ( 28991256) Serum alkaline phosphatase levels ( 31666285 29403010) Sex hormone-binding globulin levels ( 22829776) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total bilirubin levels ( 29403010) Triglyceride levels ( 32203549 28334899 32154731 29403010 31928498) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068 25961943 20686565) Type 2 diabetes ( 28406950 32499647) Urate levels ( 31578528) Vascular endothelial growth factor levels ( 26910538 27989323) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) White blood cell count ( 27863252)	Ankylosing spondylitis ( 30946743) Diisocyanate-induced asthma ( 25918132) Heschl's gyrus morphology ( 25130324) Metabolite levels ( 23823483) Opioid use cessation ( 31936517) Toenail selenium levels ( 25343990)
Interacting Genes		14 interacting genes: AR ESR2 GADD45A MT2A MYOM2 NUDT21 PPARG PSMC1 RNF168 RNF8 RXRA SRPK2 THRB TK1	14 interacting genes: ANKRD1 CKM DYSF HSPB2 JMJD1C MYBPC2 MYH7 MYH9 NEB RPS6 SEC31A TAF1 TNNT1 TTN
Entrez ID		221037	9172
HPRD ID		05141	04619
Ensembl ID		ENSG00000171988	ENSG00000036448
Uniprot IDs		B7ZLC8 Q15652	P54296
PDB IDs		2YPD 5FZO
Enriched GO Terms of Interacting Partners?
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