FCER1G and SLC1A1

Data Source:
BioGRID (two hybrid)

		FCER1G	SLC1A1
Description		Fc fragment of IgE receptor Ig	solute carrier family 1 member 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Fc-epsilon Receptor I Complex Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Apical Plasma Membrane Axon Dendrite Early Endosome Membrane Late Endosome Membrane Asymmetric Synapse Neuronal Cell Body Synaptic Cleft Dendritic Spine Dendritic Shaft Perikaryon Axon Terminus Recycling Endosome Membrane Extracellular Exosome Cell Periphery Glial Cell Projection Apical Dendrite Presynapse Perisynaptic Space Distal Dendrite Proximal Dendrite
	Molecular Function	Protein Binding IgE Receptor Activity IgE Binding IgG Binding Identical Protein Binding	L-glutamate Transmembrane Transporter Activity High-affinity Glutamate Transmembrane Transporter Activity Protein Binding Chloride Transmembrane Transporter Activity L-aspartate Transmembrane Transporter Activity Glutamate:sodium Symporter Activity Glutamate Binding Cysteine Transmembrane Transporter Activity Identical Protein Binding Metal Ion Binding D-aspartate Transmembrane Transporter Activity
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Neutrophil Activation Involved In Immune Response T Cell Differentiation Involved In Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Blood Coagulation Regulation Of Platelet Activation Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Platelet Activation Neutrophil Chemotaxis Receptor Internalization Positive Regulation Of Interleukin-4 Production Fc-gamma Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Interleukin-3-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Defense Response To Bacterium Neutrophil Degranulation Innate Immune Response Positive Regulation Of Phagocytosis Leukocyte Migration Cellular Response To Low-density Lipoprotein Particle Stimulus	Behavioral Fear Response Regulation Of Protein Phosphorylation Glutathione Metabolic Process Ion Transport Cellular Zinc Ion Homeostasis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Chemical Synaptic Transmission Learning Or Memory Positive Regulation Of Heart Rate Retina Layer Formation Glutamate Secretion L-glutamate Transmembrane Transport Peptidyl-serine Phosphorylation Maintenance Of Blood-brain Barrier Response To Decreased Oxygen Levels Neuron Death In Response To Oxidative Stress Cysteine Transport Blood Vessel Morphogenesis Response To Axon Injury L-glutamate Import Righting Reflex Heart Contraction Long-term Synaptic Potentiation Transepithelial Transport D-aspartate Transport L-aspartate Transmembrane Transport D-aspartate Import Across Plasma Membrane Cellular Response To Ammonium Ion Response To Anesthetic Regulation Of Protein Targeting To Membrane Glutamate Homeostasis Motor Neuron Apoptotic Process L-glutamate Import Across Plasma Membrane Neurotransmitter Receptor Transport To Plasma Membrane L-aspartate Import Across Plasma Membrane Transport Across Blood-brain Barrier Chloride Transmembrane Transport Cysteine Transmembrane Transport
Pathways		GPVI-mediated activation cascade Cell surface interactions at the vascular wall Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation Dectin-2 family Dectin-2 family Neutrophil degranulation Platelet Adhesion to exposed collagen	Glutamate Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)
Drugs		Benzylpenicilloyl polylysine	Aspartic acid Glutamic acid
Diseases			Dicarboxylic aminoaciduria
GWAS		Aggressive periodontitis ( 28449029) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184 31361310) Allergy ( 27182965) Asthma ( 31361310 30929738 32296059 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Mean platelet volume ( 32888494 27863252) Neutrophil count ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) White blood cell count ( 32888494)	Coronary artery calcification ( 23870195) Metabolite levels ( 23823483) Pancreatic cancer ( 22158540) Response to antipsychotic treatment in schizophrenia ( 29503163) Response to risperidone in schizophrenia ( 29503163) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		83 interacting genes: ADGRE2 C2CD2L CDIPT CERS4 CLCA4 CLEC4E CNIH1 COX20 CYP4F2 DEFB127 DGAT2L6 EBP FA2H FAM209A FAXDC2 FCER1A FCGR3A FFAR2 FUNDC2 FXYD6 GIMAP5 GJA5 GP6 GPR61 IER3IP1 KCNA1 KCNN3 KIR2DL4 LEPROTL1 LMNA LNPEP LYN MFF MGLL NCR1 NCR3 NRM ORMDL2 PDZK1IP1 PEMT PEX16 PLCG2 PLP2 RUSF1 SEC22B SFXN1 SFXN3 SLC10A1 SLC13A4 SLC18A1 SLC1A1 SLC30A8 SLC35G2 SLC38A7 SLC39A2 SLC39A9 SLC7A1 SLC7A14 SMIM1 STX12 SYK SYNJ2BP SYS1 THBD TMEM107 TMEM120B TMEM140 TMEM14B TMEM179B TMEM19 TMEM218 TMEM31 TPRG1 TSPO TSPO2 UBE2J1 UBIAD1 UNC50 UNC93A VAMP1 YIF1A YIPF4 YIPF6	16 interacting genes: APP ARL6IP5 C1GALT1 ERGIC3 EWSR1 FAM209A FCER1G FXYD3 LDLRAD1 LMNA PAGE1 PRKCA RNF5 SLC35A1 SYNPR TMEM179B
Entrez ID		2207	6505
HPRD ID		00916	00597
Ensembl ID		ENSG00000158869	ENSG00000106688
Uniprot IDs		P30273	P43005
PDB IDs			6S3Q
Enriched GO Terms of Interacting Partners?
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