FCER1G and ORMDL2

Data Source:
BioGRID (two hybrid)

		FCER1G	ORMDL2
Description		Fc fragment of IgE receptor Ig	ORMDL sphingolipid biosynthesis regulator 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Fc-epsilon Receptor I Complex Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Endoplasmic Reticulum Integral Component Of Membrane SPOTS Complex
	Molecular Function	Protein Binding IgE Receptor Activity IgE Binding IgG Binding Identical Protein Binding	Protein Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Neutrophil Activation Involved In Immune Response T Cell Differentiation Involved In Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Blood Coagulation Regulation Of Platelet Activation Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Platelet Activation Neutrophil Chemotaxis Receptor Internalization Positive Regulation Of Interleukin-4 Production Fc-gamma Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Interleukin-3-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Defense Response To Bacterium Neutrophil Degranulation Innate Immune Response Positive Regulation Of Phagocytosis Leukocyte Migration Cellular Response To Low-density Lipoprotein Particle Stimulus	Ceramide Metabolic Process Cellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process
Pathways		GPVI-mediated activation cascade Cell surface interactions at the vascular wall Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation Dectin-2 family Dectin-2 family Neutrophil degranulation Platelet Adhesion to exposed collagen	Sphingolipid de novo biosynthesis
Drugs		Benzylpenicilloyl polylysine
Diseases
GWAS		Aggressive periodontitis ( 28449029) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184 31361310) Allergy ( 27182965) Asthma ( 31361310 30929738 32296059 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Mean platelet volume ( 32888494 27863252) Neutrophil count ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) White blood cell count ( 32888494)	Refractive error ( 32231278)
Interacting Genes		83 interacting genes: ADGRE2 C2CD2L CDIPT CERS4 CLCA4 CLEC4E CNIH1 COX20 CYP4F2 DEFB127 DGAT2L6 EBP FA2H FAM209A FAXDC2 FCER1A FCGR3A FFAR2 FUNDC2 FXYD6 GIMAP5 GJA5 GP6 GPR61 IER3IP1 KCNA1 KCNN3 KIR2DL4 LEPROTL1 LMNA LNPEP LYN MFF MGLL NCR1 NCR3 NRM ORMDL2 PDZK1IP1 PEMT PEX16 PLCG2 PLP2 RUSF1 SEC22B SFXN1 SFXN3 SLC10A1 SLC13A4 SLC18A1 SLC1A1 SLC30A8 SLC35G2 SLC38A7 SLC39A2 SLC39A9 SLC7A1 SLC7A14 SMIM1 STX12 SYK SYNJ2BP SYS1 THBD TMEM107 TMEM120B TMEM140 TMEM14B TMEM179B TMEM19 TMEM218 TMEM31 TPRG1 TSPO TSPO2 UBE2J1 UBIAD1 UNC50 UNC93A VAMP1 YIF1A YIPF4 YIPF6	21 interacting genes: AQP6 CD79A CREB3L1 CYB561 CYB5R3 DAPK1 EBP ELOVL4 FAM210B FCER1G GJA8 KCNJ6 MMGT1 RETREG3 SCN3B SLC10A1 TMEM120A TMEM31 TMEM86B TMX2 ZDHHC15
Entrez ID		2207	29095
HPRD ID		00916	17802
Ensembl ID		ENSG00000158869	ENSG00000123353
Uniprot IDs		P30273	Q53FV1
PDB IDs
Enriched GO Terms of Interacting Partners?
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