SLC1A1 and C1GALT1

Data Source:
BioGRID (two hybrid)

		SLC1A1	C1GALT1
Description		solute carrier family 1 member 1	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Apical Plasma Membrane Axon Dendrite Early Endosome Membrane Late Endosome Membrane Asymmetric Synapse Neuronal Cell Body Synaptic Cleft Dendritic Spine Dendritic Shaft Perikaryon Axon Terminus Recycling Endosome Membrane Extracellular Exosome Cell Periphery Glial Cell Projection Apical Dendrite Presynapse Perisynaptic Space Distal Dendrite Proximal Dendrite	Golgi Membrane Integral Component Of Membrane
	Molecular Function	L-glutamate Transmembrane Transporter Activity High-affinity Glutamate Transmembrane Transporter Activity Protein Binding Chloride Transmembrane Transporter Activity L-aspartate Transmembrane Transporter Activity Glutamate:sodium Symporter Activity Glutamate Binding Cysteine Transmembrane Transporter Activity Identical Protein Binding Metal Ion Binding D-aspartate Transmembrane Transporter Activity	Protein Binding Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase Activity Metal Ion Binding
	Biological Process	Behavioral Fear Response Regulation Of Protein Phosphorylation Glutathione Metabolic Process Ion Transport Cellular Zinc Ion Homeostasis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Chemical Synaptic Transmission Learning Or Memory Positive Regulation Of Heart Rate Retina Layer Formation Glutamate Secretion L-glutamate Transmembrane Transport Peptidyl-serine Phosphorylation Maintenance Of Blood-brain Barrier Response To Decreased Oxygen Levels Neuron Death In Response To Oxidative Stress Cysteine Transport Blood Vessel Morphogenesis Response To Axon Injury L-glutamate Import Righting Reflex Heart Contraction Long-term Synaptic Potentiation Transepithelial Transport D-aspartate Transport L-aspartate Transmembrane Transport D-aspartate Import Across Plasma Membrane Cellular Response To Ammonium Ion Response To Anesthetic Regulation Of Protein Targeting To Membrane Glutamate Homeostasis Motor Neuron Apoptotic Process L-glutamate Import Across Plasma Membrane Neurotransmitter Receptor Transport To Plasma Membrane L-aspartate Import Across Plasma Membrane Transport Across Blood-brain Barrier Chloride Transmembrane Transport Cysteine Transmembrane Transport	Angiogenesis Kidney Development O-glycan Processing O-glycan Processing, Core 1 Protein Phosphopantetheinylation Cell Differentiation
Pathways		Glutamate Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)	Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) O-linked glycosylation of mucins
Drugs		Aspartic acid Glutamic acid
Diseases		Dicarboxylic aminoaciduria
GWAS		Coronary artery calcification ( 23870195) Metabolite levels ( 23823483) Pancreatic cancer ( 22158540) Response to antipsychotic treatment in schizophrenia ( 29503163) Response to risperidone in schizophrenia ( 29503163) Squamous cell lung carcinoma ( 28604730)	Blood protein levels ( 29875488) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 30224653) Erosive tooth wear (severe vs non-severe) ( 29898447) FEV1 ( 30804560) Lung function (FEV1/FVC) ( 28166213 30804560) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Multiple sclerosis (severity) ( 19010793) Night sleep phenotypes ( 27126917) Peak expiratory flow ( 30804560) Refractive error ( 32231278) Serum galactose-deficient IgA1 levels ( 28187132) Smooth-surface caries ( 24556642) Systolic blood pressure ( 26969751) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		16 interacting genes: APP ARL6IP5 C1GALT1 ERGIC3 EWSR1 FAM209A FCER1G FXYD3 LDLRAD1 LMNA PAGE1 PRKCA RNF5 SLC35A1 SYNPR TMEM179B	30 interacting genes: ANKS6 ARL13B C1GALT1C1 CD79A CPLX4 ELOVL4 FAM209A FAM210B GJA8 GJB1 GJB5 GPR101 GPR151 GPR42 GPRC5D GPX8 LEPROT LEUTX LHFPL5 MUC1 PIGP RETREG3 SLC14A1 SLC1A1 SLC7A14 STX1A TMEM14B TMEM237 TMEM52B XRN1
Entrez ID		6505	56913
HPRD ID		00597	16631
Ensembl ID		ENSG00000106688	ENSG00000106392
Uniprot IDs		P43005	A0A024RA32 Q9NS00
PDB IDs		6S3Q
Enriched GO Terms of Interacting Partners?
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