FCER1G and NCR3

Data Source:
BioGRID (two hybrid)

		FCER1G	NCR3
Description		Fc fragment of IgE receptor Ig	natural cytotoxicity triggering receptor 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Fc-epsilon Receptor I Complex Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding IgE Receptor Activity IgE Binding IgG Binding Identical Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Neutrophil Activation Involved In Immune Response T Cell Differentiation Involved In Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Blood Coagulation Regulation Of Platelet Activation Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Platelet Activation Neutrophil Chemotaxis Receptor Internalization Positive Regulation Of Interleukin-4 Production Fc-gamma Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Interleukin-3-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Defense Response To Bacterium Neutrophil Degranulation Innate Immune Response Positive Regulation Of Phagocytosis Leukocyte Migration Cellular Response To Low-density Lipoprotein Particle Stimulus	Immune Response-activating Cell Surface Receptor Signaling Pathway Inflammatory Response Immune Response Cell Recognition Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response
Pathways		GPVI-mediated activation cascade Cell surface interactions at the vascular wall Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation Dectin-2 family Dectin-2 family Neutrophil degranulation Platelet Adhesion to exposed collagen	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs		Benzylpenicilloyl polylysine
Diseases
GWAS		Aggressive periodontitis ( 28449029) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184 31361310) Allergy ( 27182965) Asthma ( 31361310 30929738 32296059 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Mean platelet volume ( 32888494 27863252) Neutrophil count ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) White blood cell count ( 32888494)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Hypertension ( 30226566) Inflammatory bowel disease ( 28067908) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213) Malaria ( 31844061) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Rosacea symptom severity ( 29771307) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Takayasu arteritis ( 25604533) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 28067908) Weight ( 19079260)
Interacting Genes		83 interacting genes: ADGRE2 C2CD2L CDIPT CERS4 CLCA4 CLEC4E CNIH1 COX20 CYP4F2 DEFB127 DGAT2L6 EBP FA2H FAM209A FAXDC2 FCER1A FCGR3A FFAR2 FUNDC2 FXYD6 GIMAP5 GJA5 GP6 GPR61 IER3IP1 KCNA1 KCNN3 KIR2DL4 LEPROTL1 LMNA LNPEP LYN MFF MGLL NCR1 NCR3 NRM ORMDL2 PDZK1IP1 PEMT PEX16 PLCG2 PLP2 RUSF1 SEC22B SFXN1 SFXN3 SLC10A1 SLC13A4 SLC18A1 SLC1A1 SLC30A8 SLC35G2 SLC38A7 SLC39A2 SLC39A9 SLC7A1 SLC7A14 SMIM1 STX12 SYK SYNJ2BP SYS1 THBD TMEM107 TMEM120B TMEM140 TMEM14B TMEM179B TMEM19 TMEM218 TMEM31 TPRG1 TSPO TSPO2 UBE2J1 UBIAD1 UNC50 UNC93A VAMP1 YIF1A YIPF4 YIPF6	5 interacting genes: BAG6 CD247 CD59 FAM209A FCER1G
Entrez ID		2207	259197
HPRD ID		00916	11384
Ensembl ID		ENSG00000158869	ENSG00000204475
Uniprot IDs		P30273	O14931 Q05D23
PDB IDs			3NOI 3PV6 6YJP
Enriched GO Terms of Interacting Partners?
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