ORMDL2 and GJA8

Data Source:
BioGRID (two hybrid)

		ORMDL2	GJA8
Description		ORMDL sphingolipid biosynthesis regulator 2	gap junction protein alpha 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Integral Component Of Membrane SPOTS Complex	Integral Component Of Plasma Membrane Connexin Complex
	Molecular Function	Protein Binding	Gap Junction Channel Activity Protein Binding Identical Protein Binding
	Biological Process	Ceramide Metabolic Process Cellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process	Lens Development In Camera-type Eye Cell-cell Signaling Transmembrane Transport Gap Junction-mediated Intercellular Transport
Pathways		Sphingolipid de novo biosynthesis	Gap junction assembly
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Retinopathy x type 2 diabetes interaction ( 32541925)
Interacting Genes		21 interacting genes: AQP6 CD79A CREB3L1 CYB561 CYB5R3 DAPK1 EBP ELOVL4 FAM210B FCER1G GJA8 KCNJ6 MMGT1 RETREG3 SCN3B SLC10A1 TMEM120A TMEM31 TMEM86B TMX2 ZDHHC15	121 interacting genes: ABL1 ACKR2 APOA2 APOD APOL3 AQP4 ARL6IP6 ATP6V0B C1GALT1 C2CD2L C3orf52 CCDC167 CCL4 CD53 CIAO2A CLDN19 CLDN4 CLEC1A CLN6 COX20 CTXN3 CXCL16 CYBC1 CYP4F2 DEFB121 DOLK ERMP1 FDFT1 FXYD6 GIMAP1 GIMAP5 GJB2 GPR108 GPR151 GPR61 GUCA2A IGFBP5 INSIG2 ITGAM KIR2DL3 LAPTM4B LAT LEPROTL1 LHFPL5 MAL MALL MARCHF2 MFSD11 MFSD6 MGST2 MIP MS4A13 ORMDL2 OTOP2 P2RY13 PGAP2 PLN PMP22 PNLIPRP1 PRAF2 PROKR2 PTPRN QRFPR REEP6 RNF152 RUSF1 RXFP4 S1PR5 SCARF1 SEC22B SEC22C SEC23A SFTPC SLC13A2 SLC13A5 SLC16A12 SLC16A13 SLC16A3 SLC30A3 SLC35A4 SLC35F1 SLC35F6 SLC38A4 SLC38A7 SLC39A2 SLC39A7 SLC39A9 SLC52A1 SLC66A1 SLC66A2 SLC8A3 SMCO4 SMIM1 STX1B STX8 THSD7B TJP1 TMBIM6 TMEM100 TMEM107 TMEM121 TMEM128 TMEM147 TMEM182 TMEM239 TMEM242 TMEM243 TMEM42 TMEM45A TMEM60 TMEM65 TMEM72 TMEM86B TSPAN33 TWSG1 UBXN8 UNC93A UPK1B VAMP5 YIF1A YIPF6
Entrez ID		29095	2703
HPRD ID		17802	02939
Ensembl ID		ENSG00000123353	ENSG00000121634
Uniprot IDs		Q53FV1	P48165 X5D7G1
PDB IDs
Enriched GO Terms of Interacting Partners?
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