FBLN1 and ALG10

Data Source:
BioGRID (two hybrid)

		FBLN1	ALG10
Description		fibulin 1	ALG10 alpha-1,2-glucosyltransferase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Fibronectin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein C-terminus Binding Peptidase Activator Activity Identical Protein Binding Protein-containing Complex Binding Fibrinogen Binding	Protein Binding Dolichyl Pyrophosphate Glc2Man9GlcNAc2 Alpha-1,2-glucosyltransferase Activity
	Biological Process	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Peptidase Activity Viral Process Extracellular Matrix Organization Negative Regulation Of ERK1 And ERK2 Cascade Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Cell Motility Negative Regulation Of Stem Cell Proliferation	Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Drugs
Diseases		Synpolydactyly, 3/3'4, associated with metacarpal and metatarsal synostoses
GWAS		Blood protein levels ( 30072576) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Low density lipoprotein cholesterol levels ( 32154731) Paneth cell defects in Crohn's disease ( 28352666) QT interval ( 29213071) Red blood cell count ( 27863252) Temperament (bipolar disorder) ( 22365631)	Chronotype ( 30696823) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Methadone dose in opioid dependence ( 28115739) Morning person ( 30696823) Triglyceride levels ( 32203549)
Interacting Genes		62 interacting genes: ACAN ADAMTSL2 ADAMTSL4 AK3 ALG10 APOA1 APP ATN1 BHLHE40 CACNA1A CCN2 CCN3 CHIC2 CREB5 CXCL5 DDIAS ECM1 EDC4 ELN FGB FN1 GFI1B HBEGF HOXA1 HSPG2 ITGB1 KRTAP11-1 KRTAP19-2 LCE1A LCE1B LCE1C LCE1F LCE3A LCE5A LINGO1 LMNTD2 LTBP4 MCPH1 MEOX2 MFAP5 MOB4 MRPL12 NEDD1 NID1 NLGN3 NOTCH3 PAX5 PLSCR1 PPARA SKIL SLC66A2 SMAD3 SMAD4 SPRY1 TAF9 TANK TCF7L2 TDGF1 TRIM42 UNKL VCAN YWHAQ	8 interacting genes: CD79A ERGIC3 FBLN1 HERPUD2 KCNH1 KCNH2 SERP2 SHISAL1
Entrez ID		2192	84920
HPRD ID		00629	10346
Ensembl ID		ENSG00000077942	ENSG00000139133
Uniprot IDs		P23142 Q8NBH6	Q5BKT4
PDB IDs
Enriched GO Terms of Interacting Partners?
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