FBLN1 and LTBP4

Data Source:
BioGRID (two hybrid)

		FBLN1	LTBP4
Description		fibulin 1	latent transforming growth factor beta binding protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber	Microfibril Extracellular Region Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Fibronectin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein C-terminus Binding Peptidase Activator Activity Identical Protein Binding Protein-containing Complex Binding Fibrinogen Binding	Transforming Growth Factor Beta-activated Receptor Activity Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Transforming Growth Factor Beta Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Peptidase Activity Viral Process Extracellular Matrix Organization Negative Regulation Of ERK1 And ERK2 Cascade Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Cell Motility Negative Regulation Of Stem Cell Proliferation	Regulation Of Cell Growth Protein Folding Transforming Growth Factor Beta Receptor Signaling Pathway Multicellular Organism Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Proteolysis Growth Hormone Secretion Regulation Of Cell Differentiation
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres	Molecules associated with elastic fibres
Drugs
Diseases		Synpolydactyly, 3/3'4, associated with metacarpal and metatarsal synostoses	Cutis laxa with severe pulmonary, gastrointestinal, and urinary abnormalities; Urban-Rifkin-Davis syndrome
GWAS		Blood protein levels ( 30072576) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Low density lipoprotein cholesterol levels ( 32154731) Paneth cell defects in Crohn's disease ( 28352666) QT interval ( 29213071) Red blood cell count ( 27863252) Temperament (bipolar disorder) ( 22365631)	Appendicular lean mass ( 33097823) Carotid intima media thickness (mean) ( 31801372) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lung function (FEV1/FVC) ( 26635082 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Red blood cell count ( 32888494)
Interacting Genes		62 interacting genes: ACAN ADAMTSL2 ADAMTSL4 AK3 ALG10 APOA1 APP ATN1 BHLHE40 CACNA1A CCN2 CCN3 CHIC2 CREB5 CXCL5 DDIAS ECM1 EDC4 ELN FGB FN1 GFI1B HBEGF HOXA1 HSPG2 ITGB1 KRTAP11-1 KRTAP19-2 LCE1A LCE1B LCE1C LCE1F LCE3A LCE5A LINGO1 LMNTD2 LTBP4 MCPH1 MEOX2 MFAP5 MOB4 MRPL12 NEDD1 NID1 NLGN3 NOTCH3 PAX5 PLSCR1 PPARA SKIL SLC66A2 SMAD3 SMAD4 SPRY1 TAF9 TANK TCF7L2 TDGF1 TRIM42 UNKL VCAN YWHAQ	11 interacting genes: ATN1 ATXN7 CACNA1A CRKL CRY1 FBLN1 FRAT1 GFI1B ITSN2 RAC1 TGFB1
Entrez ID		2192	8425
HPRD ID		00629	05274
Ensembl ID		ENSG00000077942	ENSG00000090006
Uniprot IDs		P23142 Q8NBH6	A0A0C4DH07 B3KXY6 Q8N2S1
PDB IDs
Enriched GO Terms of Interacting Partners?
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