FBLN1 and AK3

Data Source:
BioGRID (two hybrid)

		FBLN1	AK3
Description		fibulin 1	adenylate kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Fibronectin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein C-terminus Binding Peptidase Activator Activity Identical Protein Binding Protein-containing Complex Binding Fibrinogen Binding	Adenylate Kinase Activity Protein Binding ATP Binding GTP Binding Nucleoside Triphosphate Adenylate Kinase Activity
	Biological Process	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Peptidase Activity Viral Process Extracellular Matrix Organization Negative Regulation Of ERK1 And ERK2 Cascade Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Cell Motility Negative Regulation Of Stem Cell Proliferation	ADP Biosynthetic Process Blood Coagulation Nucleoside Triphosphate Biosynthetic Process Phosphorylation AMP Metabolic Process GTP Metabolic Process ITP Metabolic Process UTP Metabolic Process Nucleoside Monophosphate Phosphorylation
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases		Synpolydactyly, 3/3'4, associated with metacarpal and metatarsal synostoses
GWAS		Blood protein levels ( 30072576) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Low density lipoprotein cholesterol levels ( 32154731) Paneth cell defects in Crohn's disease ( 28352666) QT interval ( 29213071) Red blood cell count ( 27863252) Temperament (bipolar disorder) ( 22365631)	Crohn's disease ( 22412388) Hematological parameters ( 19820697) Mean corpuscular hemoglobin ( 27863252) Mean spheric corpuscular volume ( 32888494) Platelet count ( 26805783 22139419 29403010 20139978) White blood cell count ( 27863252)
Interacting Genes		62 interacting genes: ACAN ADAMTSL2 ADAMTSL4 AK3 ALG10 APOA1 APP ATN1 BHLHE40 CACNA1A CCN2 CCN3 CHIC2 CREB5 CXCL5 DDIAS ECM1 EDC4 ELN FGB FN1 GFI1B HBEGF HOXA1 HSPG2 ITGB1 KRTAP11-1 KRTAP19-2 LCE1A LCE1B LCE1C LCE1F LCE3A LCE5A LINGO1 LMNTD2 LTBP4 MCPH1 MEOX2 MFAP5 MOB4 MRPL12 NEDD1 NID1 NLGN3 NOTCH3 PAX5 PLSCR1 PPARA SKIL SLC66A2 SMAD3 SMAD4 SPRY1 TAF9 TANK TCF7L2 TDGF1 TRIM42 UNKL VCAN YWHAQ	6 interacting genes: APPBP2 DAPK3 FBLN1 KRTAP10-8 TRIM54 ZDHHC17
Entrez ID		2192	50808
HPRD ID		00629	12439
Ensembl ID		ENSG00000077942	ENSG00000147853
Uniprot IDs		P23142 Q8NBH6	Q7Z4Y4 Q9UIJ7
PDB IDs			1ZD8 6ZJB 6ZJD 6ZJE
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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