UHRF2 and CD27

Data Source:
BioGRID (far western blotting)

		UHRF2	CD27
Description		ubiquitin like with PHD and ring finger domains 2	CD27 molecule
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GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Pericentric Heterochromatin	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Histone Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Transmembrane Signaling Receptor Activity Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Cell Cycle Maintenance Of DNA Methylation Protein Ubiquitination Cell Differentiation Regulation Of Cell Cycle Protein Autoubiquitination Positive Regulation Of Cell Cycle Arrest	Cell Surface Receptor Signaling Pathway Immunoglobulin Mediated Immune Response Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Ethanol Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of T Cell Apoptotic Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling
Pathways		SUMOylation of transcription cofactors	TNFs bind their physiological receptors
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31959851 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Periodontal microbiota ( 22699663)	Crohn's disease ( 26192919)
Interacting Genes		38 interacting genes: ATXN1 BAX BCAR1 BCL2L1 CCND1 CD27 CDK1 CDK2 CDK4 CDK6 CTNNB1 DESI1 FANCD2 FYN H3C1 JAK3 LCK LYN MCL1 PCNP PTPRC RAD51 RBCK1 RUNX1 SKP1 SMAD4 TP53 TRIM27 TRIM8 UBE2D1 UBE2D2 UBE2D4 UBE2K UBE2W UHRF1 YY1 ZNF410 ZNF618	8 interacting genes: ACTN2 CD70 CIB1 SIVA1 TRAF2 TRAF3 TRAF5 UHRF2
Entrez ID		115426	939
HPRD ID		18257	01723
Ensembl ID		ENSG00000147854	ENSG00000139193
Uniprot IDs		Q96PU4	P26842
PDB IDs		1WY8 1Z6U 2E6S 3OLN 4PW5 4PW6 4PW7 4TVR 5YCO	5TL5 5TLJ 5TLK
Enriched GO Terms of Interacting Partners?
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