FBL and PRMT3

Data Source:
BioGRID (enzymatic study)

		FBL	PRMT3
Description		fibrillarin	protein arginine methyltransferase 3
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GO Annotations	Cellular Component	Fibrillar Center Dense Fibrillar Component Nucleus Nucleoplasm Chromosome Nucleolus Cajal Body Membrane Box C/D RNP Complex Small-subunit Processome Extracellular Exosome	Cytoplasm Cytosol
	Molecular Function	TFIID-class Transcription Factor Complex Binding RNA Binding Protein Binding RRNA Methyltransferase Activity ATPase Binding Histone-glutamine Methyltransferase Activity	Protein Binding Methyltransferase Activity Protein-arginine N-methyltransferase Activity Ribosome Binding Metal Ion Binding
	Biological Process	Box C/D RNA 3'-end Processing Osteoblast Differentiation RRNA Processing RRNA Methylation SnoRNA Localization Histone Glutamine Methylation	Protein Methylation Negative Regulation Of Protein Ubiquitination Peptidyl-arginine N-methylation
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	RMTs methylate histone arginines Protein methylation
Drugs			S-adenosyl-L-homocysteine
Diseases
GWAS			Carotid intima media thickness (maximum) ( 31801372) Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906) Pursuit maintenance gain ( 29064472) Response to inhaled glucocorticoid treatment in asthma (change in FEV1) ( 25601762)
Interacting Genes		22 interacting genes: DDX17 DDX5 ERG H2AC20 KLF6 MAP3K14 PIN4 PRMT1 PRMT3 PRMT6 PRMT8 PSMB6 PTEN RUVBL1 RUVBL2 SIRT7 SMN1 SMN2 SNRPN TAF9 TBC1D17 ZNF792	11 interacting genes: BEND7 FBL HNRNPA1 MEOX2 PABPN1 PIH1D2 PPARD RASSF2 RPS2 STAT1 TSC22D2
Entrez ID		2091	10196
HPRD ID		00617	11934
Ensembl ID		ENSG00000105202	ENSG00000185238
Uniprot IDs		P22087	O60678 Q8WUV3
PDB IDs		2IPX	2FYT 3SMQ 4HSG 4QQN 4RYL
Enriched GO Terms of Interacting Partners?
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