PRMT3 and TSC22D2

Data Source:
BioGRID (two hybrid)

		PRMT3	TSC22D2
Description		protein arginine methyltransferase 3	TSC22 domain family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Protein Binding Methyltransferase Activity Protein-arginine N-methyltransferase Activity Ribosome Binding Metal Ion Binding
	Biological Process	Protein Methylation Negative Regulation Of Protein Ubiquitination Peptidyl-arginine N-methylation	Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress
Pathways		RMTs methylate histone arginines Protein methylation
Drugs		S-adenosyl-L-homocysteine
Diseases
GWAS		Carotid intima media thickness (maximum) ( 31801372) Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906) Pursuit maintenance gain ( 29064472) Response to inhaled glucocorticoid treatment in asthma (change in FEV1) ( 25601762)	Adiponectin levels ( 22479202) Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cortical surface area (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 29891935) HDL cholesterol levels ( 32203549) Intraocular pressure ( 29235454) Macular thickness ( 30535121) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444) Moyamoya disease ( 29273593) PR interval ( 32439900) Pulse pressure ( 27841878) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) Triglyceride levels ( 32203549 32154731) Type 2 diabetes ( 30054458 30297969) Waist circumference ( 26785701)
Interacting Genes		11 interacting genes: BEND7 FBL HNRNPA1 MEOX2 PABPN1 PIH1D2 PPARD RASSF2 RPS2 STAT1 TSC22D2	42 interacting genes: ANAPC10 ANKRD36 ARID2 ATP1B1 CCDC141 CCDC144A CLIP1 DNAAF11 ENOPH1 EPCAM F8 FLNB GPBP1 ITGA2 KIAA0586 LOXHD1 LPL MED13 MPDZ MSH3 MTIF2 NGRN OSBPL1A PRMT3 PSMA7 PSMA8 RBL1 REV1 RNF2 SAP18 SCEL SEC31A SNX3 SPEF2 STK39 TMA7 TTN UFM1 WNK3 ZMYM2 ZNF143 ZNF251
Entrez ID		10196	9819
HPRD ID		11934	11101
Ensembl ID		ENSG00000185238	ENSG00000196428
Uniprot IDs		O60678 Q8WUV3	B4DN36 O75157
PDB IDs		2FYT 3SMQ 4HSG 4QQN 4RYL
Enriched GO Terms of Interacting Partners?
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