DUSP12 and HSPB8

Data Source:
BioGRID (two hybrid)

		DUSP12	HSPB8
Description		dual specificity phosphatase 12	heat shock protein family B (small) member 8
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body Chaperone Complex
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Zinc Ion Binding Phosphatase Activity Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Protein Kinase Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Cellular Protein Modification Process Protein Dephosphorylation Dephosphorylation Positive Regulation Of Glucokinase Activity Peptidyl-tyrosine Dephosphorylation	Protein Phosphorylation Cellular Response To Unfolded Protein Regulation Of Cellular Response To Heat Positive Regulation Of Aggrephagy
Pathways			HSF1-dependent transactivation
Drugs
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Distal hereditary motor neuropathies (dHMN)
GWAS		Albumin-globulin ratio ( 29403010) Immunoglobulin measurement (zinc sulfate turbidity test) ( 29403010) Non-albumin protein levels ( 29403010)	Metabolite levels ( 23823483) PR interval in Tripanosoma cruzi seropositivity ( 24324551)
Interacting Genes		13 interacting genes: APP CALCOCO2 CCNH CEP126 EIF5 HSPB8 M6PR MBD6 NR1H2 PPP2R3B PTN RABAC1 USO1	22 interacting genes: ATXN7L2 BAG3 C2CD6 CRYAB CSNK2A1 DUSP12 FAM214B HSPB1 HSPB2 HSPB3 HSPB6 HSPB7 MAPK3 MISP MLF2 PRKCA QRICH1 RPIA SLC16A5 SNCA SOCS7 TRAPPC6A
Entrez ID		11266	26353
HPRD ID		05323	06420
Ensembl ID		ENSG00000081721	ENSG00000152137
Uniprot IDs		Q9UNI6	Q9UJY1
PDB IDs		4JNB 4KI9
Enriched GO Terms of Interacting Partners?
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