DUSP12 and M6PR

Data Source:
BioGRID (two hybrid)

		DUSP12	M6PR
Description		dual specificity phosphatase 12	mannose-6-phosphate receptor, cation dependent
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Lysosomal Membrane Endosome Late Endosome Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Membrane Transport Vesicle Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Zinc Ion Binding Phosphatase Activity Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Transmembrane Signaling Receptor Activity Protein Binding Protein Domain Specific Binding Retromer Complex Binding
	Biological Process	Cellular Protein Modification Process Protein Dephosphorylation Dephosphorylation Positive Regulation Of Glucokinase Activity Peptidyl-tyrosine Dephosphorylation	Protein Targeting To Lysosome Receptor-mediated Endocytosis Lysosomal Transport Endosome To Lysosome Transport Secretion Of Lysosomal Enzymes Membrane Organization
Pathways			Lysosome Vesicle Biogenesis Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Alglucosidase alfa 1-3 Sugar Ring of Pentamannosyl 6-Phosphate alpha-D-mannose 6-phosphate
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Immunoglobulin measurement (zinc sulfate turbidity test) ( 29403010) Non-albumin protein levels ( 29403010)	SjÃ¶gren's syndrome ( 28076899) Total cholesterol levels ( 30275531)
Interacting Genes		13 interacting genes: APP CALCOCO2 CCNH CEP126 EIF5 HSPB8 M6PR MBD6 NR1H2 PPP2R3B PTN RABAC1 USO1	12 interacting genes: DUSP12 GGA1 GGA2 GGA3 GIMAP5 HSPA12A JUN KTN1 NINJ2 PLIN3 REN SMCO4
Entrez ID		11266	4074
HPRD ID		05323	01106
Ensembl ID		ENSG00000081721	ENSG00000003056
Uniprot IDs		Q9UNI6	F5GX30 P20645
PDB IDs		4JNB 4KI9	1JUQ
Enriched GO Terms of Interacting Partners?
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