DUSP6 and ZNF212

Data Source:
BioGRID (two hybrid)

		DUSP6	ZNF212
Description		dual specificity phosphatase 6	zinc finger protein 212
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Nucleoplasm
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Inactivation Of MAPK Activity Protein Dephosphorylation Response To Organic Cyclic Compound Cell Differentiation Peptidyl-tyrosine Dephosphorylation Peptidyl-threonine Dephosphorylation Response To Drug Positive Regulation Of Apoptotic Process Response To Nitrosative Stress Regulation Of Heart Growth Negative Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II
Pathways		RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway Signaling by MAPK mutants	Generic Transcription Pathway
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 29325848 30478444) Night sleep phenotypes ( 27126917)	Metabolite levels ( 23823483)
Interacting Genes		12 interacting genes: AATK ERBB4 LMTK2 LTK MAPK1 MAPK3 MDFI ROR2 SRPK1 TEX11 TXK ZNF212	30 interacting genes: - ATF3 ATF4 BYSL CREB3L2 CSK DPF2 DUSP6 FAM90A1 FHL2 GAS8 GNL1 GYS1 HBP1 KANK2 MLH1 NFKBIA NKX2-3 PPARGC1B PRKAA2 PTP4A1 RND1 SAP30BP SF3A3 SUV39H2 ZNF3 ZNF331 ZNF408 ZNF783 ZZZ3
Entrez ID		1848	7988
HPRD ID		04124	03859
Ensembl ID		ENSG00000139318	ENSG00000170260
Uniprot IDs		A0A024RBC1 Q16828 Q53GP9	A0A090N8N3 B3KQE6 Q9UDV6
PDB IDs		1HZM 1MKP
Enriched GO Terms of Interacting Partners?
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