DUSP6 and LMTK2

Data Source:
BioGRID (two hybrid)

		DUSP6	LMTK2
Description		dual specificity phosphatase 6	lemur tyrosine kinase 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Early Endosome Golgi Apparatus Cytosol Integral Component Of Plasma Membrane Integral Component Of Membrane Growth Cone Neuronal Cell Body Receptor Complex Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Phosphatase Inhibitor Activity Protein Binding ATP Binding Myosin VI Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	MAPK Cascade Activation Of MAPK Activity Inactivation Of MAPK Activity Protein Dephosphorylation Response To Organic Cyclic Compound Cell Differentiation Peptidyl-tyrosine Dephosphorylation Peptidyl-threonine Dephosphorylation Response To Drug Positive Regulation Of Apoptotic Process Response To Nitrosative Stress Regulation Of Heart Growth Negative Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor	Receptor Recycling Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axonogenesis Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Endocytic Recycling Negative Regulation Of Phosphoprotein Phosphatase Activity Transferrin Transport Positive Regulation Of Kinase Activity Early Endosome To Late Endosome Transport Protein Autophosphorylation
Pathways		RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway Signaling by MAPK mutants
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 29325848 30478444) Night sleep phenotypes ( 27126917)	Gamma glutamyl transferase levels ( 29403010) Hemoglobin levels ( 32327693) Prostate cancer ( 18264097)
Interacting Genes		12 interacting genes: AATK ERBB4 LMTK2 LTK MAPK1 MAPK3 MDFI ROR2 SRPK1 TEX11 TXK ZNF212	24 interacting genes: CDC14A CDC25C CDK5 CDK5R1 DUSP14 DUSP19 DUSP29 DUSP6 ILKAP MTMR6 PPM1A PPM1F PPM1K PPP1CA PPP1CB PPP1CC PPP1R2 PPP3CB PTPDC1 PTPN12 PTPN6 PTPRR STYX TPTE2
Entrez ID		1848	22853
HPRD ID		04124	13994
Ensembl ID		ENSG00000139318	ENSG00000164715
Uniprot IDs		A0A024RBC1 Q16828 Q53GP9	Q8IWU2
PDB IDs		1HZM 1MKP
Enriched GO Terms of Interacting Partners?
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