DHPS and RAB27B

Data Source:
BioGRID (two hybrid)

		DHPS	RAB27B
Description		deoxyhypusine synthase	RAB27B, member RAS oncogene family
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Late Endosome Golgi Stack Plasma Membrane Apical Plasma Membrane Trans-Golgi Network Transport Vesicle Secretory Granule Platelet Dense Granule Membrane Multivesicular Body Membrane Melanosome Zymogen Granule Membrane Extracellular Exosome Anchored Component Of Synaptic Vesicle Membrane Axon Cytoplasm
	Molecular Function	Protein Binding Deoxyhypusine Synthase Activity Identical Protein Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Translation Spermidine Metabolic Process Positive Regulation Of Cell Population Proliferation Peptidyl-lysine Modification To Peptidyl-hypusine	Platelet Degranulation Melanosome Transport Positive Regulation Of Exocytosis Synaptic Vesicle Endocytosis Multivesicular Body Sorting Pathway Anterograde Axonal Protein Transport
Pathways		Hypusine synthesis from eIF5A-lysine	Platelet degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs		1-Guanidinium-7-Aminoheptane
Diseases
GWAS		Platelet distribution width ( 32888494)	Adult body size ( 32376654) Allergic disease (asthma, hay fever or eczema) ( 29083406) Body mass index ( 28892062) Body size at age 10 ( 32376654) Childhood body mass index ( 26604143) Depression ( 29700475) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		16 interacting genes: BRCA1 EIF5A EIF5A2 LNX1 MEOX2 NIF3L1 NTAQ1 NUDT18 PAX6 PTPRH RAB27B RBP1 REL RPL9 VASH1 ZNF138	11 interacting genes: DHPS GORASP2 MLPH MYRIP RPH3A RPH3AL SYTL1 SYTL2 SYTL4 SYTL5 UNC13D
Entrez ID		1725	5874
HPRD ID		02969	04846
Ensembl ID		ENSG00000095059	ENSG00000041353
Uniprot IDs		A0A024R7D0 A0A024R7E9 P49366	O00194
PDB IDs		1DHS 1RLZ 1ROZ 1RQD 6P4V 6PGR 6WKZ 6WL6 6XXH 6XXI 6XXJ 6XXK 6XXL 6XXM	2F7S
Enriched GO Terms of Interacting Partners?
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