DHPS and EIF5A

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (in vitro, in vivo)

		DHPS	EIF5A
Description		deoxyhypusine synthase	eukaryotic translation initiation factor 5A
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Annulate Lamellae Nuclear Pore Cytoplasm Endoplasmic Reticulum Membrane Cytosol Membrane
	Molecular Function	Protein Binding Deoxyhypusine Synthase Activity Identical Protein Binding	RNA Binding Translation Elongation Factor Activity Protein Binding U6 SnRNA Binding Ribosome Binding Protein N-terminus Binding
	Biological Process	Translation Spermidine Metabolic Process Positive Regulation Of Cell Population Proliferation Peptidyl-lysine Modification To Peptidyl-hypusine	MRNA Export From Nucleus Translational Elongation Protein Export From Nucleus Nucleocytoplasmic Transport Apoptotic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Translational Elongation Positive Regulation Of Translational Termination
Pathways		Hypusine synthesis from eIF5A-lysine	Hypusine synthesis from eIF5A-lysine
Drugs		1-Guanidinium-7-Aminoheptane
Diseases
GWAS		Platelet distribution width ( 32888494)	Venous thromboembolism ( 31420334)
Interacting Genes		16 interacting genes: BRCA1 EIF5A EIF5A2 LNX1 MEOX2 NIF3L1 NTAQ1 NUDT18 PAX6 PTPRH RAB27B RBP1 REL RPL9 VASH1 ZNF138	17 interacting genes: CRX DHPS DOHH GSC2 LBX1 MEI4 MEOX2 PICK1 REL RPL5 SDCBP STUB1 SUMO2 TGM2 XPO1 XPO4 XRN2
Entrez ID		1725	1984
HPRD ID		02969	02555
Ensembl ID		ENSG00000095059	ENSG00000132507
Uniprot IDs		A0A024R7D0 A0A024R7E9 P49366	P63241
PDB IDs		1DHS 1RLZ 1ROZ 1RQD 6P4V 6PGR 6WKZ 6WL6 6XXH 6XXI 6XXJ 6XXK 6XXL 6XXM	1FH4 3CPF 5DLQ
Enriched GO Terms of Interacting Partners?
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