RNF168 and KDM4A

Data Source:
BioGRID (enzymatic study)

		RNF168	KDM4A
Description		ring finger protein 168	lysine demethylase 4A
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol Protein-containing Complex Site Of Double-strand Break	Fibrillar Center Nucleus Nucleoplasm Cytosol
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Nucleosome Binding Histone Binding Ubiquitin Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Histone Demethylase Activity Histone Demethylase Activity (H3-K9 Specific) Methylated Histone Binding Histone Demethylase Activity (H3-K36 Specific)
	Biological Process	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Response To Ionizing Radiation Protein Ubiquitination Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2A Monoubiquitination Interstrand Cross-link Repair Histone H2A-K13 Ubiquitination Histone H2A-K15 Ubiquitination Isotype Switching Positive Regulation Of DNA Repair Protein K63-linked Ubiquitination Histone H2A K63-linked Ubiquitination	Chromatin Remodeling Negative Regulation Of Autophagy Negative Regulation Of Gene Expression Viral Process Histone Demethylation Histone H3-K9 Demethylation Negative Regulation Of Transcription, DNA-templated Histone H3-K36 Demethylation
Pathways		SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	HDMs demethylate histones Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases		RIDDLE syndrome
GWAS		Fat distribution (HIV) ( 21897333) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Triglyceride levels ( 32203549)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Household income (MTAG) ( 31844048) Menarche (age at onset) ( 25231870) Number of sexual partners ( 30643258) Perceived intensity of sweet substances ( 31005972) Red blood cell count ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656) Smoking status (ever vs never smokers) ( 30643258) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		32 interacting genes: ALAS1 ECPAS H2AC13 H2AC18 H2AC20 H2AC4 H2AX H2AZ1 H2BC21 JMJD1C KDM1A KDM4A LAPTM5 PALB2 PARP1 RABGEF1 RNF11 RNF126 SQSTM1 SUMO2 TNFAIP3 TOP2A TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G2 UBE2L3 USP7 WBP2	5 interacting genes: H3C1 H4C1 RB1 RNF168 RNF8
Entrez ID		165918	9682
HPRD ID		08190	17168
Ensembl ID		ENSG00000163961	ENSG00000066135
Uniprot IDs		Q8IYW5	O75164
PDB IDs		3L11 4GB0 5XIS 5XIT 5XIU 5YDK	2GF7 2GFA 2GP3 2GP5 2OQ6 2OQ7 2OS2 2OT7 2OX0 2P5B 2PXJ 2Q8C 2Q8D 2Q8E 2QQR 2QQS 2VD7 2WWJ 2YBK 2YBP 2YBS 3NJY 3PDQ 3RVH 3U4S 4AI9 4BIS 4GD4 4URA 4V2V 4V2W 5A7N 5A7O 5A7P 5A7Q 5A7S 5A7W 5A80 5ANQ 5D6W 5D6X 5D6Y 5F2S 5F2W 5F32 5F37 5F39 5F3C 5F3E 5F3G 5F3I 5F5I 5FPV 5FWE 5FY8 5FYC 5FYH 5FYI 5LY1 5LY2 5TVR 5TVS 5VAR 5VGI 5VMP 6CG1 6CG2 6G5W 6G5X 6H4O 6H4P 6H4Q 6H4R 6H4S 6H4T 6H4U 6H4V 6H4W 6H4X 6H4Y 6H8P 6HGT 7D4A
Enriched GO Terms of Interacting Partners?
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