RNF168 and H2AC18

Data Source:
BioGRID (pull down)

		RNF168	H2AC18
Description		ring finger protein 168	H2A clustered histone 18
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol Protein-containing Complex Site Of Double-strand Break	Nucleosome Nucleus Extracellular Exosome
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Nucleosome Binding Histone Binding Ubiquitin Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Molecular_function DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Response To Ionizing Radiation Protein Ubiquitination Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2A Monoubiquitination Interstrand Cross-link Repair Histone H2A-K13 Ubiquitination Histone H2A-K15 Ubiquitination Isotype Switching Positive Regulation Of DNA Repair Protein K63-linked Ubiquitination Histone H2A K63-linked Ubiquitination	Chromatin Silencing Biological_process
Pathways		SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 UCH proteinases Ub-specific processing proteases Metalloprotease DUBs Deposition of new CENPA-containing nucleosomes at the centromere RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation
Drugs
Diseases		RIDDLE syndrome
GWAS		Fat distribution (HIV) ( 21897333) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Triglyceride levels ( 32203549)
Interacting Genes		32 interacting genes: ALAS1 ECPAS H2AC13 H2AC18 H2AC20 H2AC4 H2AX H2AZ1 H2BC21 JMJD1C KDM1A KDM4A LAPTM5 PALB2 PARP1 RABGEF1 RNF11 RNF126 SQSTM1 SUMO2 TNFAIP3 TOP2A TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G2 UBE2L3 USP7 WBP2	20 interacting genes: APP BAP1 BMI1 DNAJC2 H2BC15 IL33 MSL2 NOC2L PARP1 PRMT6 RCC1 RNF168 RNF169 RNF2 RNF20 TBL1X UBC UBE2H USP16 USP21
Entrez ID		165918	8337
HPRD ID		08190	08851
Ensembl ID		ENSG00000163961	ENSG00000203812
Uniprot IDs		Q8IYW5	Q6FI13
PDB IDs		3L11 4GB0 5XIS 5XIT 5XIU 5YDK	6SE6 6SEE 6SEF 6SEG 6Y5D
Enriched GO Terms of Interacting Partners?
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