RNF168 and H2AZ1

Data Source:
BioGRID (pull down)

		RNF168	H2AZ1
Description		ring finger protein 168	H2A.Z variant histone 1
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol Protein-containing Complex Site Of Double-strand Break	Nucleosome Euchromatin Heterochromatin Barr Body Nucleus Extracellular Exosome
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Nucleosome Binding Histone Binding Ubiquitin Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding Protein Heterodimerization Activity
	Biological Process	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Response To Ionizing Radiation Protein Ubiquitination Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2A Monoubiquitination Interstrand Cross-link Repair Histone H2A-K13 Ubiquitination Histone H2A-K15 Ubiquitination Isotype Switching Positive Regulation Of DNA Repair Protein K63-linked Ubiquitination Histone H2A K63-linked Ubiquitination	Chromatin Silencing Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus
Pathways		SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Deposition of new CENPA-containing nucleosomes at the centromere RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation
Drugs
Diseases		RIDDLE syndrome
GWAS		Fat distribution (HIV) ( 21897333) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Triglyceride levels ( 32203549)
Interacting Genes		32 interacting genes: ALAS1 ECPAS H2AC13 H2AC18 H2AC20 H2AC4 H2AX H2AZ1 H2BC21 JMJD1C KDM1A KDM4A LAPTM5 PALB2 PARP1 RABGEF1 RNF11 RNF126 SQSTM1 SUMO2 TNFAIP3 TOP2A TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G2 UBE2L3 USP7 WBP2	7 interacting genes: FH INCENP MAGEC1 NCAPH RNF168 RNF169 USP16
Entrez ID		165918	3015
HPRD ID		08190	00823
Ensembl ID		ENSG00000163961	ENSG00000164032
Uniprot IDs		Q8IYW5	P0C0S5
PDB IDs		3L11 4GB0 5XIS 5XIT 5XIU 5YDK	1F66 3WA9 4CAY 4NFT 5B31 5B32 5B33 5CHL 5FUG 5Z30 6JOU 6KO2
Enriched GO Terms of Interacting Partners?
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