CYLC2 and MUTYH

Data Source:
BioGRID (two hybrid)

		CYLC2	MUTYH
Description		cylicin 2	mutY DNA glycosylase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoskeletal Calyx	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	Structural Constituent Of Cytoskeleton	Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Protein Binding DNA N-glycosylase Activity Oxidized Purine DNA Binding MutLalpha Complex Binding MutLbeta Complex Binding MutSalpha Complex Binding MutSbeta Complex Binding 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Adenine/guanine Mispair Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Cytoskeleton Organization Multicellular Organism Development Spermatogenesis Cell Differentiation	DNA Repair Base-excision Repair Mismatch Repair Depurination
Pathways
Drugs
Diseases			Familial adenomatous polyposis
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)	Composite immunoglobulin trait (IgA/IgM) ( 28628107) Periventricular white matter hyperintensities ( 32517579)
Interacting Genes		13 interacting genes: AURKA BUB1 CDKN2A EGFR ERBB2 MAP2K4 MCC MLH1 MLH3 MUTYH NRAS SMAD2 STK11	19 interacting genes: AGTRAP APEX1 BAAT CYLC2 FANCC HRAS LMNA LRSAM1 MSANTD3 MSH6 PCNA RPA1 RPA4 SEC61B SIRT6 SMAD1 TDRD7 TSTD2 XPA
Entrez ID		1539	4595
HPRD ID		04945	05380
Ensembl ID		ENSG00000155833	ENSG00000132781
Uniprot IDs		A0A024R146 Q14093 Q6PEJ5	D3DPZ6 E5KP25 E5KP26 E5KP27 E5KP28 E9PM53 Q9UIF7
PDB IDs			1X51 3N5N
Enriched GO Terms of Interacting Partners?
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